Polysaccharide-fullerene supramolecular hybrids: Synthesis, characterization and antioxidant activity
Аутори
Kop, TatjanaJakovljević, Dragica
Živković, Ljiljana S.
Žekić, Andrijana
Beškoski, Vladimir
Milić, Dragana
Gojgić-Cvijović, Gordana
Bjelaković, Mira
Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт
An efficient encapsulation of the fullerene into two hydrophobized and one native polysaccharide provided water soluble supramolecular hybrids. After covalent modification of polysaccharides by cholesterol, noncovalent hybrids were prepared by a three-step procedure, including mixing of individual aqueous solutions of hydrophobized, as well as native sugar with solution of the fullerene in pyridine, dialysis and lyophilization. Although the degree of the fullerene incorporation into hydrophobized substrates, cholesterol-levan and cholesterol-pullulan, was lower in comparison to the native polysaccharide levan, hydrophobization provided nanoparticles with improved properties. The particle size distribution, studied by dynamic light scattering and scanning electron microscopy revealed formation of moderately polydisperse aggregates, with the diameter contraction in comparison to the corresponding free polysaccharide, especially in the case of hydrophobized substrates. The morphological e...xamination, done by scanning electron microscopy indicated the self-organization of the fullerene-native polysaccharide to round individual structures, while fullerene-hydrophobized polysaccharide hybrids tend to form networks. The antioxidant activity of the synthesized polysaccharide-C60 noncovalent hybrids versus starting polysaccharides was investigated by the DPPH radical scavenging and the β-carotene-linoleic acid bleaching methods. In all three complexes, the radical scavenging ability of the fullerene remained preserved, and a positive effect of levan hydrophobization was observed.
Кључне речи:
Antioxidant activity / Cholesterol-levan conjugate / DLS / Hydrophobized polysaccharides / Polysaccharide-C60 nanoparticles / SEMИзвор:
European Polymer Journal, 2020, 123, 109461-Издавач:
- Elsevier
Финансирање / пројекти:
- Дизајн, синтеза и испитивање наномолекулских машина на бази фулерена (RS-MESTD-Basic Research (BR or ON)-172002)
- Симултана биоремедијација и соилификација деградираних простора, за очување природних ресурса биолошки активних супстанци и развој и производњу биоматеријала и дијететских производа (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43004)
Напомена:
- This is the peer-reviewed version of the manuscript: Kop, T.J., Jakovljević, D.M., Živković, L.S., Žekić, A., Beškoski, V.P., Milić, D.R., Gojgić-Cvijović, G.D., Bjelaković, M.S., Polysaccharide-fullerene supramolecular hybrids: synthesis, characterization and antioxidant activity, European Polymer Journal (2019), doi: https://doi.org/10.1016/j.eurpolymj.2019.109461
- The published version: http://cer.ihtm.bg.ac.rs/handle/123456789/3332
DOI: 10.1016/j.eurpolymj.2019.109461
ISSN: 0014-3057
WoS: 000510956600028
Scopus: 2-s2.0-85077109347
Институција/група
IHTMTY - JOUR AU - Kop, Tatjana AU - Jakovljević, Dragica AU - Živković, Ljiljana S. AU - Žekić, Andrijana AU - Beškoski, Vladimir AU - Milić, Dragana AU - Gojgić-Cvijović, Gordana AU - Bjelaković, Mira PY - 2020 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3336 AB - An efficient encapsulation of the fullerene into two hydrophobized and one native polysaccharide provided water soluble supramolecular hybrids. After covalent modification of polysaccharides by cholesterol, noncovalent hybrids were prepared by a three-step procedure, including mixing of individual aqueous solutions of hydrophobized, as well as native sugar with solution of the fullerene in pyridine, dialysis and lyophilization. Although the degree of the fullerene incorporation into hydrophobized substrates, cholesterol-levan and cholesterol-pullulan, was lower in comparison to the native polysaccharide levan, hydrophobization provided nanoparticles with improved properties. The particle size distribution, studied by dynamic light scattering and scanning electron microscopy revealed formation of moderately polydisperse aggregates, with the diameter contraction in comparison to the corresponding free polysaccharide, especially in the case of hydrophobized substrates. The morphological examination, done by scanning electron microscopy indicated the self-organization of the fullerene-native polysaccharide to round individual structures, while fullerene-hydrophobized polysaccharide hybrids tend to form networks. The antioxidant activity of the synthesized polysaccharide-C60 noncovalent hybrids versus starting polysaccharides was investigated by the DPPH radical scavenging and the β-carotene-linoleic acid bleaching methods. In all three complexes, the radical scavenging ability of the fullerene remained preserved, and a positive effect of levan hydrophobization was observed. PB - Elsevier T2 - European Polymer Journal T1 - Polysaccharide-fullerene supramolecular hybrids: Synthesis, characterization and antioxidant activity VL - 123 SP - 109461 DO - 10.1016/j.eurpolymj.2019.109461 ER -
@article{ author = "Kop, Tatjana and Jakovljević, Dragica and Živković, Ljiljana S. and Žekić, Andrijana and Beškoski, Vladimir and Milić, Dragana and Gojgić-Cvijović, Gordana and Bjelaković, Mira", year = "2020", abstract = "An efficient encapsulation of the fullerene into two hydrophobized and one native polysaccharide provided water soluble supramolecular hybrids. After covalent modification of polysaccharides by cholesterol, noncovalent hybrids were prepared by a three-step procedure, including mixing of individual aqueous solutions of hydrophobized, as well as native sugar with solution of the fullerene in pyridine, dialysis and lyophilization. Although the degree of the fullerene incorporation into hydrophobized substrates, cholesterol-levan and cholesterol-pullulan, was lower in comparison to the native polysaccharide levan, hydrophobization provided nanoparticles with improved properties. The particle size distribution, studied by dynamic light scattering and scanning electron microscopy revealed formation of moderately polydisperse aggregates, with the diameter contraction in comparison to the corresponding free polysaccharide, especially in the case of hydrophobized substrates. The morphological examination, done by scanning electron microscopy indicated the self-organization of the fullerene-native polysaccharide to round individual structures, while fullerene-hydrophobized polysaccharide hybrids tend to form networks. The antioxidant activity of the synthesized polysaccharide-C60 noncovalent hybrids versus starting polysaccharides was investigated by the DPPH radical scavenging and the β-carotene-linoleic acid bleaching methods. In all three complexes, the radical scavenging ability of the fullerene remained preserved, and a positive effect of levan hydrophobization was observed.", publisher = "Elsevier", journal = "European Polymer Journal", title = "Polysaccharide-fullerene supramolecular hybrids: Synthesis, characterization and antioxidant activity", volume = "123", pages = "109461", doi = "10.1016/j.eurpolymj.2019.109461" }
Kop, T., Jakovljević, D., Živković, L. S., Žekić, A., Beškoski, V., Milić, D., Gojgić-Cvijović, G.,& Bjelaković, M.. (2020). Polysaccharide-fullerene supramolecular hybrids: Synthesis, characterization and antioxidant activity. in European Polymer Journal Elsevier., 123, 109461. https://doi.org/10.1016/j.eurpolymj.2019.109461
Kop T, Jakovljević D, Živković LS, Žekić A, Beškoski V, Milić D, Gojgić-Cvijović G, Bjelaković M. Polysaccharide-fullerene supramolecular hybrids: Synthesis, characterization and antioxidant activity. in European Polymer Journal. 2020;123:109461. doi:10.1016/j.eurpolymj.2019.109461 .
Kop, Tatjana, Jakovljević, Dragica, Živković, Ljiljana S., Žekić, Andrijana, Beškoski, Vladimir, Milić, Dragana, Gojgić-Cvijović, Gordana, Bjelaković, Mira, "Polysaccharide-fullerene supramolecular hybrids: Synthesis, characterization and antioxidant activity" in European Polymer Journal, 123 (2020):109461, https://doi.org/10.1016/j.eurpolymj.2019.109461 . .