The anticancer activity evaluation of novel organotin(IV) compunds containing 2-propanoic acid derivatives
Procena antikancerogene aktivnosti novih organokalaj(IV) jedinjenja koja sadrže derivate 2-propanske kiseline
Apstrakt
Two novel organotin(IV) compounds containing 2-propanoic acid derivatives were synthesized and characterized by standard spectroscopic methods. In vitro antiproliferative activity of these complexes was investigated versus four tumor cell lines: PC3 (prostate), HT-29 (colon), MCF-7 (breast) and HepG2 (hepatic) using MTT and CV assays. The results have shown that that synthesized complexes exhibit remarkable anticancer activity toward all tested cell lines with 54 to 113 fold higher activity than the reference compound cisplatin. The obtained promising results indicate the necessity for further in vitro/in vivo research with the aim to investigate the mechanism of action of these potencial antitumor agents.
Dva nova organokalaj(IV) jedinjenja, koja sadrže derivate 2-propanske kiseline, sintetisana su i okarakterisana pomoću standardnih spektroskopskih metoda. In vitro antiproliferativna aktivnost ovih jedinjenja ispitana je prema četiri tumorske ćelijske linije: PC3 (prostata), HT-29 (debelo crevo), MCF-7 (dojka) i HepG2 (jetra) pomoću MTT and CV testova. Rezultati ispitivanja ukazuju da sintetisana jedinjenja ispoljavaju izvanrednu antikancerogenu aktivnost prema svim ispitanim ćelijskim linijama i njihova aktivnost je od 54 do 113 puta veća od aktivnosti referentne supstance, cisplatine. Dobijeni rezultati ukazuju na neophodnost daljih in vitro/in vivo istraživanja sa ciljem ispitivanja mehanizma delovanja ovih potencijalnih antitumorskih agenasa.
Ključne reči:
organotin(IV) compounds / in vitro antiproliferative activity / potencial antitumor agentsIzvor:
56th Meeting of the Serbian chemical Society - Book of Abstracts / 56. Savetovanje Srpskog hemijskog društva - Kratki izvodi radova, Niš 7-8.9. 2019., 2019, 84-Izdavač:
- Serbian Chemical Society, Belgrade / Srpsko hemijsko društvo, Beograd
Finansiranje / projekti:
- Racionalni dizajn i sinteza biološki aktivnih i koordinacionih jedinjenja i funkcionalnih materijala, relevantnih u (bio)nanotehnologiji (RS-MESTD-Basic Research (BR or ON)-172035)
Institucija/grupa
IHTMTY - CONF AU - Pantelić, Nebojša AU - Zmejkovski, Bojana AU - Banjac, Nebojša R. AU - Božić, Bojan AU - Kaluđerović, Goran N. PY - 2019 UR - https://www.shd.org.rs/index.php/abstracts-56 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3301 AB - Two novel organotin(IV) compounds containing 2-propanoic acid derivatives were synthesized and characterized by standard spectroscopic methods. In vitro antiproliferative activity of these complexes was investigated versus four tumor cell lines: PC3 (prostate), HT-29 (colon), MCF-7 (breast) and HepG2 (hepatic) using MTT and CV assays. The results have shown that that synthesized complexes exhibit remarkable anticancer activity toward all tested cell lines with 54 to 113 fold higher activity than the reference compound cisplatin. The obtained promising results indicate the necessity for further in vitro/in vivo research with the aim to investigate the mechanism of action of these potencial antitumor agents. AB - Dva nova organokalaj(IV) jedinjenja, koja sadrže derivate 2-propanske kiseline, sintetisana su i okarakterisana pomoću standardnih spektroskopskih metoda. In vitro antiproliferativna aktivnost ovih jedinjenja ispitana je prema četiri tumorske ćelijske linije: PC3 (prostata), HT-29 (debelo crevo), MCF-7 (dojka) i HepG2 (jetra) pomoću MTT and CV testova. Rezultati ispitivanja ukazuju da sintetisana jedinjenja ispoljavaju izvanrednu antikancerogenu aktivnost prema svim ispitanim ćelijskim linijama i njihova aktivnost je od 54 do 113 puta veća od aktivnosti referentne supstance, cisplatine. Dobijeni rezultati ukazuju na neophodnost daljih in vitro/in vivo istraživanja sa ciljem ispitivanja mehanizma delovanja ovih potencijalnih antitumorskih agenasa. PB - Serbian Chemical Society, Belgrade / Srpsko hemijsko društvo, Beograd C3 - 56th Meeting of the Serbian chemical Society - Book of Abstracts / 56. Savetovanje Srpskog hemijskog društva - Kratki izvodi radova, Niš 7-8.9. 2019. T1 - The anticancer activity evaluation of novel organotin(IV) compunds containing 2-propanoic acid derivatives T1 - Procena antikancerogene aktivnosti novih organokalaj(IV) jedinjenja koja sadrže derivate 2-propanske kiseline SP - 84 UR - https://hdl.handle.net/21.15107/rcub_cer_3301 ER -
@conference{ author = "Pantelić, Nebojša and Zmejkovski, Bojana and Banjac, Nebojša R. and Božić, Bojan and Kaluđerović, Goran N.", year = "2019", abstract = "Two novel organotin(IV) compounds containing 2-propanoic acid derivatives were synthesized and characterized by standard spectroscopic methods. In vitro antiproliferative activity of these complexes was investigated versus four tumor cell lines: PC3 (prostate), HT-29 (colon), MCF-7 (breast) and HepG2 (hepatic) using MTT and CV assays. The results have shown that that synthesized complexes exhibit remarkable anticancer activity toward all tested cell lines with 54 to 113 fold higher activity than the reference compound cisplatin. The obtained promising results indicate the necessity for further in vitro/in vivo research with the aim to investigate the mechanism of action of these potencial antitumor agents., Dva nova organokalaj(IV) jedinjenja, koja sadrže derivate 2-propanske kiseline, sintetisana su i okarakterisana pomoću standardnih spektroskopskih metoda. In vitro antiproliferativna aktivnost ovih jedinjenja ispitana je prema četiri tumorske ćelijske linije: PC3 (prostata), HT-29 (debelo crevo), MCF-7 (dojka) i HepG2 (jetra) pomoću MTT and CV testova. Rezultati ispitivanja ukazuju da sintetisana jedinjenja ispoljavaju izvanrednu antikancerogenu aktivnost prema svim ispitanim ćelijskim linijama i njihova aktivnost je od 54 do 113 puta veća od aktivnosti referentne supstance, cisplatine. Dobijeni rezultati ukazuju na neophodnost daljih in vitro/in vivo istraživanja sa ciljem ispitivanja mehanizma delovanja ovih potencijalnih antitumorskih agenasa.", publisher = "Serbian Chemical Society, Belgrade / Srpsko hemijsko društvo, Beograd", journal = "56th Meeting of the Serbian chemical Society - Book of Abstracts / 56. Savetovanje Srpskog hemijskog društva - Kratki izvodi radova, Niš 7-8.9. 2019.", title = "The anticancer activity evaluation of novel organotin(IV) compunds containing 2-propanoic acid derivatives, Procena antikancerogene aktivnosti novih organokalaj(IV) jedinjenja koja sadrže derivate 2-propanske kiseline", pages = "84", url = "https://hdl.handle.net/21.15107/rcub_cer_3301" }
Pantelić, N., Zmejkovski, B., Banjac, N. R., Božić, B.,& Kaluđerović, G. N.. (2019). The anticancer activity evaluation of novel organotin(IV) compunds containing 2-propanoic acid derivatives. in 56th Meeting of the Serbian chemical Society - Book of Abstracts / 56. Savetovanje Srpskog hemijskog društva - Kratki izvodi radova, Niš 7-8.9. 2019. Serbian Chemical Society, Belgrade / Srpsko hemijsko društvo, Beograd., 84. https://hdl.handle.net/21.15107/rcub_cer_3301
Pantelić N, Zmejkovski B, Banjac NR, Božić B, Kaluđerović GN. The anticancer activity evaluation of novel organotin(IV) compunds containing 2-propanoic acid derivatives. in 56th Meeting of the Serbian chemical Society - Book of Abstracts / 56. Savetovanje Srpskog hemijskog društva - Kratki izvodi radova, Niš 7-8.9. 2019.. 2019;:84. https://hdl.handle.net/21.15107/rcub_cer_3301 .
Pantelić, Nebojša, Zmejkovski, Bojana, Banjac, Nebojša R., Božić, Bojan, Kaluđerović, Goran N., "The anticancer activity evaluation of novel organotin(IV) compunds containing 2-propanoic acid derivatives" in 56th Meeting of the Serbian chemical Society - Book of Abstracts / 56. Savetovanje Srpskog hemijskog društva - Kratki izvodi radova, Niš 7-8.9. 2019. (2019):84, https://hdl.handle.net/21.15107/rcub_cer_3301 .