Biogenic amines content in the serum of patients with non-Hodgkin’s lymphoma
Samo za registrovane korisnike
2019
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The biosynthetic pathway of biogenic amines is very active during the growth of many tumour cells. Non-Hodgkin lymphoma represents a very heterogeneous group of malignancies. The concentration level of some biogenic amines (putrescine, histamine, spermidine, epinephrine, and spermine) was investigated to elucidate whether they could be observed as markers for the patients with non-Hodgkin’s lymphoma. In this study, the method of acidic extraction of five biogenic amines from human serum, dansyl chloride pre-column derivatization, and LC/DAD analysis were used to determine the content of biogenic amines in biological fluids. The results indicate that statistically significant differences exist in putrescine, spermidine and histamine contents in non-Hodgkin’s patients versus healthy controls. The concentrations of putrescine, spermidine and epinephrine were elevated, and histamine was lower compared to controls. Based on their content, serum biogenic amines could be considered as potenti...al tumour markers.
Ključne reči:
Biogenic amines / LC/DAD / serum / non-Hodgkin's lymphomaIzvor:
Revue Roumaine de Chimie, 2019, 64, 8, 681-686Izdavač:
- Editura Academiei Romane
Finansiranje / projekti:
- Racionalni dizajn i sinteza biološki aktivnih i koordinacionih jedinjenja i funkcionalnih materijala, relevantnih u (bio)nanotehnologiji (RS-MESTD-Basic Research (BR or ON)-172035)
DOI: 10.3224/rrch.2019.64.8.05
ISSN: 0035-3930
WoS: 000495592100005
Scopus: 2-s2.0-85074940032
Institucija/grupa
IHTMTY - JOUR AU - Trifunović-Macedoljan, Jelena AU - Pantelić, Nebojša Đ. AU - Jadranin, Milka AU - Juranić, Ivan PY - 2019 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3261 AB - The biosynthetic pathway of biogenic amines is very active during the growth of many tumour cells. Non-Hodgkin lymphoma represents a very heterogeneous group of malignancies. The concentration level of some biogenic amines (putrescine, histamine, spermidine, epinephrine, and spermine) was investigated to elucidate whether they could be observed as markers for the patients with non-Hodgkin’s lymphoma. In this study, the method of acidic extraction of five biogenic amines from human serum, dansyl chloride pre-column derivatization, and LC/DAD analysis were used to determine the content of biogenic amines in biological fluids. The results indicate that statistically significant differences exist in putrescine, spermidine and histamine contents in non-Hodgkin’s patients versus healthy controls. The concentrations of putrescine, spermidine and epinephrine were elevated, and histamine was lower compared to controls. Based on their content, serum biogenic amines could be considered as potential tumour markers. PB - Editura Academiei Romane T2 - Revue Roumaine de Chimie T1 - Biogenic amines content in the serum of patients with non-Hodgkin’s lymphoma VL - 64 IS - 8 SP - 681 EP - 686 DO - 10.3224/rrch.2019.64.8.05 ER -
@article{ author = "Trifunović-Macedoljan, Jelena and Pantelić, Nebojša Đ. and Jadranin, Milka and Juranić, Ivan", year = "2019", abstract = "The biosynthetic pathway of biogenic amines is very active during the growth of many tumour cells. Non-Hodgkin lymphoma represents a very heterogeneous group of malignancies. The concentration level of some biogenic amines (putrescine, histamine, spermidine, epinephrine, and spermine) was investigated to elucidate whether they could be observed as markers for the patients with non-Hodgkin’s lymphoma. In this study, the method of acidic extraction of five biogenic amines from human serum, dansyl chloride pre-column derivatization, and LC/DAD analysis were used to determine the content of biogenic amines in biological fluids. The results indicate that statistically significant differences exist in putrescine, spermidine and histamine contents in non-Hodgkin’s patients versus healthy controls. The concentrations of putrescine, spermidine and epinephrine were elevated, and histamine was lower compared to controls. Based on their content, serum biogenic amines could be considered as potential tumour markers.", publisher = "Editura Academiei Romane", journal = "Revue Roumaine de Chimie", title = "Biogenic amines content in the serum of patients with non-Hodgkin’s lymphoma", volume = "64", number = "8", pages = "681-686", doi = "10.3224/rrch.2019.64.8.05" }
Trifunović-Macedoljan, J., Pantelić, N. Đ., Jadranin, M.,& Juranić, I.. (2019). Biogenic amines content in the serum of patients with non-Hodgkin’s lymphoma. in Revue Roumaine de Chimie Editura Academiei Romane., 64(8), 681-686. https://doi.org/10.3224/rrch.2019.64.8.05
Trifunović-Macedoljan J, Pantelić NĐ, Jadranin M, Juranić I. Biogenic amines content in the serum of patients with non-Hodgkin’s lymphoma. in Revue Roumaine de Chimie. 2019;64(8):681-686. doi:10.3224/rrch.2019.64.8.05 .
Trifunović-Macedoljan, Jelena, Pantelić, Nebojša Đ., Jadranin, Milka, Juranić, Ivan, "Biogenic amines content in the serum of patients with non-Hodgkin’s lymphoma" in Revue Roumaine de Chimie, 64, no. 8 (2019):681-686, https://doi.org/10.3224/rrch.2019.64.8.05 . .