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Half-sandwich ruthenium(II)-arene complexes: synthesis, spectroscopic studies, biological properties, and molecular modeling
dc.creator | Nikolić, Stefan | |
dc.creator | Grgurić-Šipka, Sanja | |
dc.creator | Đorđević, Ivana | |
dc.creator | Dahmani, Rahma | |
dc.creator | Dekanski, Dragana | |
dc.creator | Vidičević, Sašenka | |
dc.creator | Tošić, Jelena | |
dc.creator | Mitić, Dragana | |
dc.creator | Grubišić, Sonja | |
dc.date.accessioned | 2019-12-18T12:11:45Z | |
dc.date.available | 2019-12-18T12:11:45Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0095-8972 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/3259 | |
dc.description.abstract | In search for antitumor metal-based drugs that would mitigate the severe side-effects of cisplatin, Ru(II) complexes are gaining increasing recent interest. In this work, we report on the synthesis, characterization (1H- and 13C-NMR, FT-IR), and cytotoxicity studies of two new half-sandwich organometallic Ru(II) complexes of the general formula [Ru(η6-arene)(XY)Cl](PF6) where arene = benzene or toluene and XY = bidentates: dipyrido[3,2-a:2′,3′-c]phenazine (dppz) or 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline (aip), which are bound to Ru(II) via two phenanthroline-N atoms in a characteristic “piano-stool” configuration of Ru(II)-arene complexes—as confirmed by vibrational and NMR spectra. In addition, cytotoxic studies were performed for similar half-sandwich organometallic [Ru(η6-p-cymene)(Me2dppz)Cl]PF6 complex (Me2dppz = 11,12-dimethyl-dipyrido[3,2-a:2′,3′-c]phenazine). This study is complemented with elaborate modeling with density functional theory (DFT) calculations, which provided insight into reactive sites of Ru(II) structures, further detailed by molecular docking on the B-DNA dodecamer, which identified binding sites and affinities: most pronounced for the [Ru(η6-benzene)(aip)Cl](PF6) in both A-T and G-C regions of the DNA minor groove. Cytotoxic activity was probed versus tumor cell lines B16, C6, and U251 (B16 mouse melanoma, C6 rat glioma, U251 human glioblastoma) and non-tumor cell line HACAT (HACAT normal human keratinocytes). | en |
dc.publisher | Taylor & Francis | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.relation | COST CMST-Action CM1405 Molecules in Motion (MOLIM) | |
dc.rights | restrictedAccess | |
dc.source | Journal of Coordination Chemistry | |
dc.subject | cytotoxicity studies | |
dc.subject | DFT calculations | |
dc.subject | DNA docking | |
dc.subject | intercalation | |
dc.subject | Ruthenium complexes | |
dc.title | Half-sandwich ruthenium(II)-arene complexes: synthesis, spectroscopic studies, biological properties, and molecular modeling | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Декански, Драгана; Николић, Стефан; Гргурић-Шипка, Сања; Грубишић, Соња; Ђорђевић, Ивана; Дахмани, Рахма; Видичевић, Сашенка; Тошић, Јелена; Митић, Драгана; | |
dc.citation.volume | 72 | |
dc.citation.issue | 1 | |
dc.citation.spage | 148 | |
dc.citation.epage | 163 | |
dc.citation.rank | M22~ | |
dc.description.other | Peer-reviewed manuscript: [http://cer.ihtm.bg.ac.rs/handle/123456789/3260] | |
dc.identifier.doi | 10.1080/00958972.2018.1553298 | |
dc.identifier.scopus | 2-s2.0-85064599205 | |
dc.identifier.wos | 000465181600009 | |
dc.type.version | publishedVersion |