Приказ основних података о документу

dc.creatorŠegan, Sandra
dc.creatorTerzić-Jovanović, Nataša
dc.creatorMilojković-Opsenica, Dušanka
dc.creatorTrifković, Jelena
dc.creatorŠolaja, Bogdan
dc.creatorOpsenica, Dejan
dc.date.accessioned2019-10-23T14:40:48Z
dc.date.available2019-05-04
dc.date.issued2014
dc.identifier.issn0731-7085
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/3166
dc.description.abstractThe chromatographic behavior of mixed 1,2,4,5-tetraoxanes, cholic and deoxycholic acid derivatives with distinct biological activity, was examined by high-performance thin-layer chromatography in order to correlate their structure and retention. Chromatographic systems were consisted of RP-18 or CN-silica as stationary phase, and binary mixtures of water with methanol, dioxane or acetone as mobile phase. Based on the respective retentions, the lipophilicity of the investigated compounds was determined. Multiple linear regression and partial least squares have been used to select variables that best describe the behavior of the investigated compounds in chromatographic systems and to quantify influences of most important parameters. The validation and cross-validation of the QSRR model suggest its applicability for prediction and understanding of retention of congeners. The models indicate the importance of nonpolar properties of the solutes and their ability for hydrophobic interactions, as well as the importance of proton donating abilities, hydrophilic and,pi interactions pointing out on that way the possible separation mechanism in the studied chromatographic systems. Observed correlations between structure and biological activity of mixed 1,2,4,5-tetraoxanes, indicate that the antimalarial activity against W2 and D6 Plasmodium falciparum strains, is governed by hydrophobic feature (measured with lipophilicity parameter), hydrophilic feature (measured with HLB, %HS, HB and HBA descriptors), and electronic feature (HOMO).en
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172008/RS//
dc.rightsembargoedAccess
dc.sourceJournal of Pharmaceutical and Biomedical Analysis
dc.subjectMixed 1,2,4,5-tetraoxanesen
dc.subjectLipophilicityen
dc.subjectQuantitative structure-retention relationship (QSRR)en
dc.subjectQuantitative structure activity relationship (QSAR)en
dc.subjectReversed-phase thin layer chromatography (RPTLC)en
dc.titleCorrelation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parametersen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractОпсеница, Дејан; Шолаја, Богдан; Трифковић, Јелена; Милојковић-Опсеница, Душанка; Терзић Јовановић, Наташа; Шеган, Сандра;
dc.citation.volume97
dc.citation.spage178
dc.citation.epage183
dc.citation.other97: 178-183
dc.citation.rankM21
dc.description.otherThis is the peer-reviewed version of the article: S. Segan, N. Terzic-Jovanovic, D. Milojkovic-Opsenica, J. Trifkovic, B. Solaja, D. Opsenica, Correlation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parameters, Journal of Pharmaceutical and Biomedical Analysis (2014), [http://dx.doi.org/10.1016/j.jpba.2014.04.029]
dc.description.other[http://cer.ihtm.bg.ac.rs/handle/123456789/1599]
dc.identifier.pmid24876068
dc.identifier.doi10.1016/j.jpba.2014.04.029
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs/bitstream/id/14364/j.jpba.2014.04.029.pdf
dc.identifier.scopus2-s2.0-84901413732
dc.identifier.wos000337780900023
dc.type.versionacceptedVersion


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