Приказ основних података о документу
Synthesis and pharmacological evaluation of several N-(2-nitrophenyl) piperazine derivatives
Sinteza i farmakološko ispitivanje novih derivata N-(2-nitrofenil) piperazina
dc.creator | Andrić, Deana | |
dc.creator | Tovilović, Gordana | |
dc.creator | Roglić, Goran | |
dc.creator | Vasković, Đurđica | |
dc.creator | Šoškić, Vukić | |
dc.creator | Tomić, Mirko | |
dc.creator | Kostić Rajačić, Slađana | |
dc.date.accessioned | 2019-01-30T17:15:32Z | |
dc.date.available | 2019-01-30T17:15:32Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/313 | |
dc.description.abstract | Six newly synthesized heterocyclic (2-nitrophenyl)piperazines, with a specific structure of the heteroaryl group, whichmimics the catechol moiety of dopamine (benzimidazoles and substituted benzimidazoles), were evaluated for their binding affinity to rat dopamine (DA), serotonin (5-HT) and _1 receptors. All compounds with a benzimidazole group had a 5-HT2A/D2 receptors binding ratio characteristic for atypical neuroleptics (>1, pK i values). Compound 7c, 4-bromo-6-{2-_4-(2-nitrophenyl)piperazin- 1-yl_ethyl}-1H-benzimidazole, expressed higher affinities for all receptor classes than clozapine. Also, it exhibited the best characteristic for atypical neuroleptics and presents a compound with the best profile for further in vivo investigations. | en |
dc.description.abstract | Sintetisano je šest heterocikličnih (2-nitrofenil)piperazina sa specifičnom heteroaril grupom, koja podražava kateholsku grupu dopamina (benzimidazoli i supstituisani benzimidazoli), i ispitan je njihov afinitet ka dopaminskim, serotoninskim i _1 receptorima. Sva jedinjenja sa benzimidazolskim grupama su pokazala 5-HT 1A/D2 odnos vezivanja karakterističan za atipične neuroleptike (>1, pK i vrednosti). Jedinjenje 7c, 4-bromo-6-{2-_4-(2-nitrofenil)piperazin-1-il_etil}-1H-benzimidazol, pokazalo je izraženiji afinitet ka svim klasama receptora u poređenju sa klozapinom i takođe predstavlja jedinjenje sa najboljim karakteristikama za dalja in vivo istraživanja. | sr |
dc.publisher | Serbian Chemical Society | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142009/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143032/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | arylpiperazines | en |
dc.subject | benzimidazoles | en |
dc.subject | dopamine receptors | en |
dc.subject | serotonin receptors | en |
dc.subject | atypical antipsychotic | en |
dc.title | Synthesis and pharmacological evaluation of several N-(2-nitrophenyl) piperazine derivatives | en |
dc.title | Sinteza i farmakološko ispitivanje novih derivata N-(2-nitrofenil) piperazina | sr |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Васковић, Ђурђица; Aндрић, Деана; Товиловић, Гордана; Шошкић, Вукић; Роглић, Горан; Томић, Мирко; Костић Рајачић, Слађана; Синтеза и фармаколошко испитивање нових деривата Н-(2-нитрофенил) пиперазина; Синтеза и фармаколошко испитивање нових деривата Н-(2-нитрофенил) пиперазина; | |
dc.citation.volume | 72 | |
dc.citation.issue | 5 | |
dc.citation.spage | 429 | |
dc.citation.epage | 435 | |
dc.citation.other | 72(5): 429-435 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.2298/JSC0705429A | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs//bitstream/id/8992/311.pdf | |
dc.identifier.scopus | 2-s2.0-34447136382 | |
dc.identifier.wos | 000247579900002 | |
dc.type.version | publishedVersion |