Show simple item record

dc.creatorŽivković, Marijana B.
dc.creatorNovaković, Irena
dc.creatorMatić, Ivana Z.
dc.creatorSladić, Dušan
dc.creatorKrstić, Natalija
dc.date.accessioned2019-06-28T12:18:53Z
dc.date.available2020-05-08
dc.date.issued2019
dc.identifier.issn0039-128X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2948
dc.description.abstractEleven new steroidal mono- and bis(semicarbazones) 2a–e, 4d and 3a–e have been prepared starting from various 3-oxo-α,β-unsaturated steroids. Mono-semicarbazones 2a–e were further subjected to ethyl chloroacetate in boiling absolute ethanol but, instead of expected intramolecular cyclocondensation reaction products, the new carbazate esters 5a-e were obtained. The structures of all synthesized compounds and identification of each E/Z isomer were deduced by elemental analysis, HRMS, NMR, and IR spectroscopy. Preliminary screening for the cytotoxic activity in vitro of the new compounds has been conducted against three cancer cell lines, K562, Jurkat and HeLa cells. HeLa cells were the most sensitive while K562 cells were the least sensitive to the cytotoxic action of the novel steroid derivatives. Compounds 2e, 3c and 5e were found to have the best but still moderate cytotoxic effects. All tested compounds showed very weak antimicrobial activities. These results demonstrate that the replacement of thioxo group with carbonyl group in steroidal hydrazone derivatives resulted in decrease in their biological activity.
dc.publisherElsevier BVen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//en
dc.rightsembargoedAccess
dc.sourceSteroidsen
dc.subject3-Oxo-α,β-unsaturated steroids
dc.subjectSemicarbazones
dc.subjectCarbazate esters
dc.subjectBiological activity
dc.titleSynthesis and preliminary screening for the biological activity of some steroidal Δ4-unsaturated semicarbazone derivativesen
dc.typearticleen
dc.rights.licenseBY-NC-NDen
dcterms.abstractКрстић, Наталија М.; Сладић, Душан М.; Матић, Ивана З.; Новаковић, Ирена Т.; Живковић, Маријана Б.;
dc.rights.holderElsevier BV
dc.citation.volume148
dc.citation.spage36
dc.citation.epage46
dc.citation.rankM22~
dc.description.otherThis is peer-reviewed version of the article: Živković, M.B., Novaković, I.T., Matić, I.Z., Sladić, D.M., Krstić, N.M., Synthesis and preliminary screening for the biological activity of some steroidal Δ 4-unsaturated semicarbazone derivatives, Steroids (2019), doi: [https://doi.org/10.1016/j.steroids.2019.04.010]
dc.description.other[http://cer.ihtm.bg.ac.rs/handle/123456789/2947]
dc.identifier.doi10.1016/j.steroids.2019.04.010
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/7206/10.1016_j.steroids.2019.04.010.pdf
dc.identifier.scopus2-s2.0-85065594815
dc.identifier.wos000474331100005
dc.type.versionacceptedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record