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dc.creatorAnđelković, Katarina
dc.creatorMilenković, Milica
dc.creatorPevec, Andrej
dc.creatorTurel, Iztok
dc.creatorMatić, Ivana Z.
dc.creatorVujčić, Miroslava
dc.creatorSladić, Dušan
dc.creatorRadanović, Dušanka
dc.creatorBradan, Gabrijela
dc.creatorBelosevic, Svetlana
dc.creatorČobeljić, Božidar
dc.date.accessioned2019-06-04T20:15:31Z
dc.date.available2019-06-27
dc.date.issued2017
dc.identifier.issn0162-0134
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2940
dc.description.abstractIn this work synthesis, characterization and crystal structures of two isothiocyanato Fe(III) complexes with 2,2'[2,6-pyridinediylbis(ethylidyne-1-hydraziny1-2-ylidene)]bis[N,N,N-trimethyl-2-oxoethanaminium] dichloride (H2LCl2) ligand, with composition [FeL(NCS)(2)]SCN center dot 2H(2)O and [FeL(NCS)(2)](2)[Fe(H2O)(NCS)(5)}4H(2)O, has been reported. Both iron(III) complexes possess the same pentagonal-bipyramidal complex cation, while the nature of their anions depends on mole ratio of NH4SCN and FeCl3 center dot 6H(2)O used in reaction. Cytotoxic activity of new Fe(III) complexes, as well as of previously synthesized isothiocyanato Co(II), Ni(II), Mn(II), Zn(II) and Cd(II) complexes with the same ligand, was tested against five human cancer cell lines (HeLa, MDA-MB-453, K562, LS174 and A549) and normal cell line MRC-5. The best activity was observed in the case of Fe(III), Co(II) and Cd(II) complexes. The investigation of potential of these complexes to induce HeLa and K562 cell cycle perturbations was also evaluated. Mechanism of cell death mode was elucidated on the basis of morphological changes of HeLa cells as well as identification of target caspases. It was established that DNA damage could be responsible for the activity of Fe(III) and Co(II) complexes. Synopsis: Pentagonal-bipyramidal Fe(III) complexes with dihydrazone of 2,6-diacetylpyridine and Girard's T reagent have been synthesized and characterized. Cytotoxic activity of Fe(III) complexes and Co(II), Ni(II), Mn (II), Zn(II) and Cd(II) complexes with the same ligand was tested. The best activity was observed in the case of Fe (III), Co(II) and Cd(II) complexes.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.relationSlovenian Research Agency [P-0175]
dc.rightsembargoedAccess
dc.sourceJournal of Inorganic Biochemistry
dc.subject2,6-diacetylpyridine dihydrazoneen
dc.subjectPentagonal-bipyramidalen
dc.subjectFe(III) complexesen
dc.subjectCrystal structureen
dc.subjectCytotoxicityen
dc.subjectDNA interactionsen
dc.titleSynthesis, characterization and crystal structures of two pentagonal-bipyramidal Fe(III) complexes with dihydrazone of 2,6-diacetylpyridine and Girard's T reagent. Anticancer properties of various metal complexes of the same liganden
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractAнђелковиц, Катарина; Певец, Aндреј; Миленковиц, Милица Р.; Цобељиц, Бозидар; Белосевиц, Светлана; Брадан, Габријела; Радановић, Душанка; Сладић, Душан; Вујчић, Мирослава; Матиц, Ивана З.; Турел, Изток;
dc.citation.volume174
dc.citation.spage137
dc.citation.epage149
dc.citation.other174: 137-149
dc.citation.rankM22
dc.description.otherThis is a peer-reviewed version of the article: [https://doi.org/10.1016/j.jinorgbio.2017.06.011]
dc.description.other[http://cer.ihtm.bg.ac.rs/handle/123456789/2137]
dc.identifier.pmid28672143
dc.identifier.doi10.1016/j.jinorgbio.2017.06.011
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/7168/0406_6.pdf
dc.identifier.scopus2-s2.0-85021421632
dc.identifier.wos000406647700014
dc.type.versionacceptedVersion


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