Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata
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Anđelković, Boban D.
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Seven new bisbibenzyls (1−7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1−7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1− 3), and the cyclic analogues, riccardins (4−7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC50 values of 5.0, 5.0, and 2.5 μM, respectively.
Keywords:liverwort / bisbibenzyls / Lunularia cruciata / structures of compounds / spectroscopic data / acyclic bisbibenzyls / perrottetins / cyclic analogues / riccardins / perrottetin and riccardin structures / phenanthrene / dihydrophenanthrene / quinone moieties / natural products / riccardin G / lung cancer / cytotoxic activity
Source:Journal of Natural Products, 2019, 82, 4, 694-701
- American Chemical Society
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
- Micromorphological, phytochemical and molecular investigations of plants - systematic, ecological and applicative aspects (RS-173029)
- Microbial diversity study and characterization of beneficial environmental microorganisms (RS-173048)
- Supporting information: https://pubs.acs.org/doi/suppl/10.1021/acs.jnatprod.8b00390/suppl_file/np8b00390_si_001.pdf