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dc.creatorTomić, Mirko
dc.creatorKundaković, M
dc.creatorButorović, B
dc.creatorJanać, B
dc.creatorAndrić, Deana
dc.creatorRoglić, Goran
dc.creatorIgnjatović, D
dc.creatorKostić Rajačić, Slađana
dc.date.accessioned2019-05-02T09:09:36Z
dc.date.available2019-05-02T09:09:36Z
dc.date.issued2004
dc.identifier.issn0960-894X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2820
dc.description.abstractSix active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and α 1 receptors. Two compounds with benztriazole group had a 5-HT 2A /D 2 binding ratio characteristic for atypical neuroleptics (>1, pK i values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D 2 , 5-HT 2A and α1 receptors and a higher affinity for 5-HT 1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats. © 2004 Elsevier Ltd. All rights reserved.
dc.publisherElsevier Ltd
dc.relationMinistry for Science, Technology and Development of Serbia, grants #1704 and #1698
dc.rightsrestrictedAccess
dc.sourceBioorganic and Medicinal Chemistry Letters
dc.subjectArylpiperazine
dc.subjectDopamine receptors
dc.subjectSerotonin receptors
dc.titlePharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractКостић-Рајачић, Слађана; Јанаћ, Б; Игњатовић, Д; Кундаковић, М; Буторовић, Б; Роглић, Горан; Aндрић, Деана; Томић, М;
dc.rights.holderElsevier
dc.citation.volume14
dc.citation.issue16
dc.citation.spage4263
dc.citation.epage4266
dc.citation.rankM21
dc.identifier.pmid15261283
dc.identifier.doi10.1016/j.bmcl.2004.06.005
dc.identifier.scopus2-s2.0-3142691095
dc.identifier.wos000222923300029
dc.type.versionpublishedVersion


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