Guaianolides from Centaurea nicolai: Antifungal activity
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Marin, Petar D.
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A new guaianolide, 3-deacetyl-9-O-acetylsalograviolide A, along with four known closely related lactones, salograviolide A, 9-O- acetylsalograviolide A, kandavanolide and salograviolide B were detected in the aerial parts of the flowering plant Centaurea nicolai. Antifungal tests performed on salograviolide A and its 9-O-acetyl and 3-O-deacetyl-9-O-acetyl derivatives revealed inhibitory activity against Aspergillus niger, A. ochraceus, Penicillium ochrochloron, Cladosporium cladosporoides, Fusarium tricinctum and Phomopsis helianthi. Neither of them was active against Trichoderma viride.
Keywords:Asteraceae / Sesquiterpene lactones / Guaianolides / Antifungal activity
Source:Phytochemistry, 1999, 52, 3, 383-386
- Elsevier Ltd
- Ministry for Science and Technology, Republic of Serbia