Oxidation products of hyperforin from Hypericum perforatum
Samo za registrovane korisnike
1998
Autori
Trifunović, SnežanaVajs, Vlatka
Macura, Slobodan
Juranić, Nenad
Djarmati, Z
Jankov, Ratko
Milosavljević, Slobodan
Članak u časopisu (Objavljena verzija)
,
Elsevier
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The isolation of two oxidation products of hyperforin from the aerial parts of Hypericum perforatum and their structure determination by means of 2D NMR methods is reported. The products had the same 1-(2-methyl-1- oxopropyl)-2,12-dioxo-3,10β-bis(3-methyl-2-butenyl)-11β-methyl-11α-(4- methyl-3-pentenyl)-5-oxatricyclo[6.3.1.0 4,8 ]-3-dodecene skeleton. In addition, one of them, with the same number of carbons as hyperforin (C 35 H 52 O 5 ), contained a 1-methyl-1-hydroxyethyl group in the 6β- position, whereas the other compound (a hemiacetal, C 32 H 46 O 5 ), presumably a degradation product of hyperforin, exhibited a 6-hydroxy function. The latter was an inseparable mixture of 6α- and 6β-hydroxy epimers undergoing (according to phase sensitive NOESY) mutual interconversion.
Ključne reči:
Hypericum perforatum / Hypericaceae / supercritical CO2 / fractionation / oxidized hyperforinsIzvor:
Phytochemistry, 1998, 49, 5, 1305-1310Izdavač:
- Elsevier
Finansiranje / projekti:
- Ministry for Science and Technology, Republic of Serbia
DOI: 10.1016/S0031-9422(97)00903-5
ISSN: 0031-9422
WoS: 000077125100024
Scopus: 2-s2.0-0032487784
Institucija/grupa
IHTMTY - JOUR AU - Trifunović, Snežana AU - Vajs, Vlatka AU - Macura, Slobodan AU - Juranić, Nenad AU - Djarmati, Z AU - Jankov, Ratko AU - Milosavljević, Slobodan PY - 1998 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2807 AB - The isolation of two oxidation products of hyperforin from the aerial parts of Hypericum perforatum and their structure determination by means of 2D NMR methods is reported. The products had the same 1-(2-methyl-1- oxopropyl)-2,12-dioxo-3,10β-bis(3-methyl-2-butenyl)-11β-methyl-11α-(4- methyl-3-pentenyl)-5-oxatricyclo[6.3.1.0 4,8 ]-3-dodecene skeleton. In addition, one of them, with the same number of carbons as hyperforin (C 35 H 52 O 5 ), contained a 1-methyl-1-hydroxyethyl group in the 6β- position, whereas the other compound (a hemiacetal, C 32 H 46 O 5 ), presumably a degradation product of hyperforin, exhibited a 6-hydroxy function. The latter was an inseparable mixture of 6α- and 6β-hydroxy epimers undergoing (according to phase sensitive NOESY) mutual interconversion. PB - Elsevier T2 - Phytochemistry T1 - Oxidation products of hyperforin from Hypericum perforatum VL - 49 IS - 5 SP - 1305 EP - 1310 DO - 10.1016/S0031-9422(97)00903-5 ER -
@article{ author = "Trifunović, Snežana and Vajs, Vlatka and Macura, Slobodan and Juranić, Nenad and Djarmati, Z and Jankov, Ratko and Milosavljević, Slobodan", year = "1998", abstract = "The isolation of two oxidation products of hyperforin from the aerial parts of Hypericum perforatum and their structure determination by means of 2D NMR methods is reported. The products had the same 1-(2-methyl-1- oxopropyl)-2,12-dioxo-3,10β-bis(3-methyl-2-butenyl)-11β-methyl-11α-(4- methyl-3-pentenyl)-5-oxatricyclo[6.3.1.0 4,8 ]-3-dodecene skeleton. In addition, one of them, with the same number of carbons as hyperforin (C 35 H 52 O 5 ), contained a 1-methyl-1-hydroxyethyl group in the 6β- position, whereas the other compound (a hemiacetal, C 32 H 46 O 5 ), presumably a degradation product of hyperforin, exhibited a 6-hydroxy function. The latter was an inseparable mixture of 6α- and 6β-hydroxy epimers undergoing (according to phase sensitive NOESY) mutual interconversion.", publisher = "Elsevier", journal = "Phytochemistry", title = "Oxidation products of hyperforin from Hypericum perforatum", volume = "49", number = "5", pages = "1305-1310", doi = "10.1016/S0031-9422(97)00903-5" }
Trifunović, S., Vajs, V., Macura, S., Juranić, N., Djarmati, Z., Jankov, R.,& Milosavljević, S.. (1998). Oxidation products of hyperforin from Hypericum perforatum. in Phytochemistry Elsevier., 49(5), 1305-1310. https://doi.org/10.1016/S0031-9422(97)00903-5
Trifunović S, Vajs V, Macura S, Juranić N, Djarmati Z, Jankov R, Milosavljević S. Oxidation products of hyperforin from Hypericum perforatum. in Phytochemistry. 1998;49(5):1305-1310. doi:10.1016/S0031-9422(97)00903-5 .
Trifunović, Snežana, Vajs, Vlatka, Macura, Slobodan, Juranić, Nenad, Djarmati, Z, Jankov, Ratko, Milosavljević, Slobodan, "Oxidation products of hyperforin from Hypericum perforatum" in Phytochemistry, 49, no. 5 (1998):1305-1310, https://doi.org/10.1016/S0031-9422(97)00903-5 . .