Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid
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Snyder, James P.
Trajković, Vladimir S.
Saičić, Radomir N.
Article (Published version)
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A C,D-seco-paclitaxel derivative 26 was prepared from taxine and tested for biological activity. Chemical reactivity of the seco-compounds proved to be substantially modified, with respects to taxoids. The corresponding C,D-seco-taxoid does not show tubulin stabilizing activity or cytotoxicity. Explanation of these observations based on molecular modeling is provided. (c) 2006 Elsevier Ltd. All rights reserved.
Keywords:taxane antitumor agents / radicals and radical reactions / medium sized rings / natural products / molecular modeling
Source:Tetrahedron, 2006, 62, 36, 8503-8514
- Pergamon-Elsevier Science Ltd, Oxford