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Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species
dc.creator | Aljančić, Ivana | |
dc.creator | Stanković, Miroslava | |
dc.creator | Tešević, Vele | |
dc.creator | Vujisić, Ljubodrag V. | |
dc.creator | Vajs, Vlatka | |
dc.creator | Milosavljević, Slobodan | |
dc.date.accessioned | 2019-04-27T13:24:00Z | |
dc.date.available | 2019-04-27T13:24:00Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1934-578X | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2738 | |
dc.description.abstract | This study was conducted to elucidate the in vitro protective effect of five flavonoids [apigenin (1), apigenin-7-O-glucoside (2), centaureidin (3), jaceidin (4) and quercetin (5)] against chromosomal damage in mitogen-induced human lymphocytes. Using the Cytochalasin-B blocked micronucleus (CBMN) assay, in which the biomarker of chromosome breakage and/or chromosome loss is the elevated frequency of micronucleus (MN) in binucleated (BN) cells, the presence of flavonoid 2 in minimal concentration (3 mu g/mL) gave a 35.5% decrease M the frequency of MN when compared with control human lymphocytes. The same concentration of flavonoids 1, 3 and 4, reduced the MN frequency by 24.4%, 28.0% and 28.0%, respectively. Higher concentrations (6 mu g/mL and 10 mu g/mL) seemed less effective. Flavonoid 5 (3 mu g/mL.) induced a slight decrease in MN frequency (5%), while higher doses (6 mu g/mL and 10 mu g/mL) provoked an increase of DNA damage. The comparable values for the cytokinesis-block proliferation index (CBPI) of the tested flavonoids and positive control suggested an inhibitory effect on lymphocyte proliferation. In the DPPH scavenging assay, flavonoids 1-4 demonstrated modest activity, in a dose-dependent manner, compared with the synthetic antioxidants BHT and Trolox, while 5 exhibited comparably high antioxidative activity. | en |
dc.publisher | Natural Products Inc, Westerville | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142053/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Natural Product Communications | |
dc.subject | Flavonoids | en |
dc.subject | CBMN | en |
dc.subject | DPPH | en |
dc.subject | BHT | en |
dc.title | Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Aљанчић, Ивана С.; Милосављевић, Слободан М.; Вајс, Влатка; Станковић, Мирослава; Тешевић, Веле; Вујисић, Љубодраг В.; | |
dc.citation.volume | 5 | |
dc.citation.issue | 5 | |
dc.citation.spage | 729 | |
dc.citation.epage | 732 | |
dc.citation.other | 5(5): 729-732 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 20521537 | |
dc.identifier.doi | 10.1177/1934578X1000500511 | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs//bitstream/id/6490/1934578x1000500511.pdf | |
dc.identifier.scopus | 2-s2.0-77954115563 | |
dc.identifier.wos | 000277750200012 | |
dc.type.version | publishedVersion |