Cytotoxic constituents of Achillea clavennae from Montenegro
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2006
Authors
Trifunović, SnežanaVajs, Vlatka
Juranić, Zorica
Žižak, Željko
Tešević, Vele
Macura, Slobodan
Milosavljević, Slobodan
Article (Published version)
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Show full item recordAbstract
Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.
Keywords:
Achillea clavennae / Asteraceae / guaianolides / bisabolenes / flavonoids / cytotoxicitySource:
Phytochemistry, 2006, 67, 9, 887-893Publisher:
- Oxford : Pergamon-Elsevier Science Ltd
Funding / projects:
- Sekundarni metaboliti samoniklih, lekovitih biljaka: izolovanje, karakterizacija i biloška aktivnost (RS-MESTD-MPN2006-2010-142053)
- Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-MESTD-MPN2006-2010-145006)
DOI: 10.1016/j.phytochem.2006.02.026
ISSN: 0031-9422
PubMed: 16616262
WoS: 000237600300007
Scopus: 2-s2.0-33646072788
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IHTMTY - JOUR AU - Trifunović, Snežana AU - Vajs, Vlatka AU - Juranić, Zorica AU - Žižak, Željko AU - Tešević, Vele AU - Macura, Slobodan AU - Milosavljević, Slobodan PY - 2006 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2713 AB - Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved. PB - Oxford : Pergamon-Elsevier Science Ltd T2 - Phytochemistry T1 - Cytotoxic constituents of Achillea clavennae from Montenegro VL - 67 IS - 9 SP - 887 EP - 893 DO - 10.1016/j.phytochem.2006.02.026 ER -
@article{ author = "Trifunović, Snežana and Vajs, Vlatka and Juranić, Zorica and Žižak, Željko and Tešević, Vele and Macura, Slobodan and Milosavljević, Slobodan", year = "2006", abstract = "Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.", publisher = "Oxford : Pergamon-Elsevier Science Ltd", journal = "Phytochemistry", title = "Cytotoxic constituents of Achillea clavennae from Montenegro", volume = "67", number = "9", pages = "887-893", doi = "10.1016/j.phytochem.2006.02.026" }
Trifunović, S., Vajs, V., Juranić, Z., Žižak, Ž., Tešević, V., Macura, S.,& Milosavljević, S.. (2006). Cytotoxic constituents of Achillea clavennae from Montenegro. in Phytochemistry Oxford : Pergamon-Elsevier Science Ltd., 67(9), 887-893. https://doi.org/10.1016/j.phytochem.2006.02.026
Trifunović S, Vajs V, Juranić Z, Žižak Ž, Tešević V, Macura S, Milosavljević S. Cytotoxic constituents of Achillea clavennae from Montenegro. in Phytochemistry. 2006;67(9):887-893. doi:10.1016/j.phytochem.2006.02.026 .
Trifunović, Snežana, Vajs, Vlatka, Juranić, Zorica, Žižak, Željko, Tešević, Vele, Macura, Slobodan, Milosavljević, Slobodan, "Cytotoxic constituents of Achillea clavennae from Montenegro" in Phytochemistry, 67, no. 9 (2006):887-893, https://doi.org/10.1016/j.phytochem.2006.02.026 . .