Synthesis of 5-azaandrostane-3β,17β-diol protected at the 17β-hydroxyl group
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In the present paper, the preparation of 3β-hydroxy-17β-dimethyl- tert-butylsilyloxy-5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost-5-en-3β-yl acetate (1) 1,2 was used as the starting material, which was transformed to the key intermediate of the synthesis, B-nor-17β-dimethyl-tert-butylsilyloxyandrost-4-en-3β-yl acetate (7).
Keywords:5-azasteroids / B-nor-17-oxoandrost-5-en-3-yl acetate / 3β-hydroxy-17β-dimethyl-tert-butylsilyloxy-5-azaandrostane
Source:Journal of the Serbian Chemical Society, 2004, 69, 11, 861-869
- Serbian Chemical Society
- Ministry of Science and Enviroment of Serbia (Part of the project “Synthesis and chemical transformations of steroidal and modified steroid molecules” – Project No. 1702)