Приказ основних података о документу

dc.creatorPopović-Đorđević, Jelena B.
dc.creatorKlaus, Anita
dc.creatorŽižak, Željko
dc.creatorMatić, Ivana Z.
dc.creatorDrakulić, Branko
dc.date.accessioned2019-04-20T11:52:20Z
dc.date.available2019-04-20T11:52:20Z
dc.date.issued2016
dc.identifier.issn1475-6366
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/2667
dc.description.abstractAntiproliferative and antibacterial activities of nine glutarimide derivatives (1–9) were reported. Cytotoxicity of compounds was tested toward three human cancer cell lines, HeLa, K562 and MDA-MB-453 by MTT assay. Compound 7 (2-benzyl-2-azaspiro[5.11]heptadecane-1,3,7-trione), containing 12-membered ketone ring, was found to be the most potent toward all tested cell lines (IC50 = 9–27 μM). Preliminary screening of antibacterial activity by a disk diffusion method showed that Gram-positive bacteria were more susceptible to the tested compounds than Gram-negative bacteria. Minimum inhibitory concentration (MIC) determined by a broth microdilution method confirmed that compounds 1, 2, 4, 6–8 and 9 inhibited the growth of all tested Gram-positive and some of the Gram-negative bacteria. The best antibacterial potential was achieved with compound 9 (ethyl 4-(1-benzyl-2,6-dioxopiperidin-3-yl)butanoate) against Bacillus cereus (MIC 0.625 mg/mL; 1.97 × 10−3 mol/L). Distinction between more and less active/inactive compounds was assessed from the pharmacophoric patterns obtained by molecular interaction fields.en
dc.language.isoensr
dc.publisherTaylor and Francis Ltdsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172032/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//sr
dc.rightsopenAccesssr
dc.sourceJournal of Enzyme Inhibition and Medicinal Chemistrysr
dc.subjectAntitumor agentssr
dc.subjectheterocyclessr
dc.subjectstructure–activity analysissr
dc.titleAntiproliferative and antibacterial activity of some glutarimide derivativesen
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractКлаус, Aнита, С.; Жижак, Жељко; Поповић-Дјордјевић, Јелена, Б.; Дракулиц, Бранко; Матић, Ивана, З.;
dc.rights.holderTaylor & Francis Groupsr
dc.citation.volume31
dc.citation.spage915
dc.citation.epage923
dc.citation.rankM21
dc.identifier.pmid26247353
dc.identifier.doi10.3109/14756366.2015.1070844
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs/bitstream/id/6327/bitstream_6327.pdf
dc.identifier.scopus2-s2.0-84939214288
dc.identifier.wos000385270300008
dc.type.versionpublishedVersionsr


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Приказ основних података о документу