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Synthesis, characterization and cytotoxity of Pd(II), Pt(II) and Pt(IV) complexes with R2edda-type esters

dc.contributor.advisorSabo, Tibor
dc.contributor.otherKaluđerović, Goran N.
dc.contributor.otherGrgurić-Šipka, Sanja
dc.contributor.otherJuranić, Zorica
dc.contributor.otherLeovac, Vukadin
dc.creatorZmejkovski, Bojana
dc.date.accessioned2019-02-04T12:34:34Z
dc.date.available2019-02-04T12:34:34Z
dc.date.issued2010
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=1150
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:7943/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=39270927
dc.identifier.urihttp://nardus.mpn.gov.rs/123456789/3497
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/2593
dc.description.abstractU ovom radu su opisane sinteze, karakterizacija i antiproliferativna aktivnost liganada u obliku hidrohloridnih soli, estara etilendiamin-N,N’-di-3-propanske kiseline (H2eddp), (S,S)-etilendiamin-N,N’-di-2-propanske kiseline ((S,S)-H2eddip) i (S,S)-etilendiamin-N,N’-di-2-(4-metil)-pentanske kiseline ((S,S)-H2eddl), kao i odgovarajućih kompleksa sa platinom(IV), platinom(II) i paladijumom(II).Sintetisano je osam novih estara, a to su izopropil i izobutil estri svih navedenih kiselina, a sa (S,S)-H2eddip dobijeni su i ciklopentil i cikloheksil estri. Ova jedinjenja su dobijena refluktovanjem suspenzije kiseline u odgovarajućem apsolutnom alkoholu kome je prethodno ukapan tionil-hlorid. Svi estri su dobijeni u obliku dihidrohlorida: [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2iBu2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2, [(S,S)-H2Cy2eddip]Cl2, [H2iPr2eddp]Cl2, [H2iBu2eddp]Cl2, [(S,S)-H2iPr2eddl]Cl2 i [(S,S)-H2iBu2eddl]Cl2. Estri su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom, a [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2 i [(S,S)-H2iBu2eddl]Cl2 urađena je i rendgenostrukturna analiza. U pokušaju sinteze ciklopentil estra (S,S)-etilendiamin-N,N'-di-2-(3-metil)-butanske kiseline (S,S)-H2eddv, dobijeni su neočekivani monokristali sastava [(S,S)-H4eddv]Br0,17Cl1,83.4C5H9OH.Kompleksi platine(IV) dobijeni su u reakciji natrijum- ili kalijum-heksahloroplatinata(IV) sa navedenim estrima. Sintetisano je pet novih kompleksa platine(IV): [PtCl4{(S,S)-iPr2eddip}], [PtCl4{(S,S)-iBu2eddip}], [PtCl4{(S,S)-cPe2eddip}], [PtCl4(iPr2eddp)] i [PtCl4(iBu2eddp)]. Ovi kompleksi su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom. Kristalna struktura određena je kompleksima [PtCl4{(S,S)-iPr2eddip}] i [PtCl4{(S,S)-cPe2eddip}]. Kompleksi platine(II) dobijeni su u reakciji kalijum-tetrahloroplatinata(II) sa estrima. Sintetisano je tri nova kompleksa platine(II): [PtCl2{(S,S)-iPr2eddip}], [PtCl2{(S,S)-iBu2eddip}] i [PtCl2{(S,S)-cPe2eddip}]. Ovi kompleksi su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom.Sedam novih kompleksa paladijuma(II): [PdCl2{(S,S)-iPr2eddip}], [PdCl{(S,S)-iPreddip}], [PdCl2{(S,S)-iBu2eddip}], [PdCl2{(S,S)-cPe2eddip}], [PdCl2{(S,S)-Cy2eddip}], [PdCl2{(S,S)-iPr2eddl}] i [PdCl2{(S,S)-iBu2eddl}] dobijeno je u reakciji kalijum-tetrahloropaladata(II) sa estrima. Ovi kompleksi su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom...sr
dc.description.abstractThis work describes synthesis, characterization and antiproliferative activity of ligands precursors, esters of ethylenediamine-N,N’-di-3-propanoic acid (H2eddp), (S,S)-ethylenediamine-N,N’-di-2-propanoic acid ((S,S)-H2eddip) and (S,S)-ethylenediamine-N,N’-di-2-(4-methyl)-pentanoic acid ((S,S)-H2eddl), as well as their complexes with platinum(IV), platinum(II) and palladium(II).Eight novel esters are synthesized, isopropyl and isobutyl esters of the mentioned acids, and cyclopentyl and cyclohexyl esters of (S,S)-H2eddip. Thionyl-chloride was intoduced into a flask containing absolute alcohol. The corresponding acid is added forming a suspension which was reflucted. All of the esters were obtained as dihydrochlorides: [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2iBu2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2, [(S,S)-H2Cy2eddip]Cl2, [H2iPr2eddp]Cl2, [H2iBu2eddp]Cl2, [(S,S)-H2iPr2eddl]Cl2, [(S,S)-H2iBu2eddl]Cl2. Esters were characterized by elemental analysis, IR and NMR spectroscopy. Crystal structures of [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2 and [(S,S)-H2iBu2eddl]Cl2 are solved by X-ray analyses. While trying to synthesize the cyclopentyl ester of (S,S)-ethylenediamine-N,N'-di-2-(3-methyl)-butanoic acid (S,S)-H2eddv, unexpected crystals suitable for X-ray analysis were obtained and determined - [(S,S)-H4eddv]Br0.17Cl1.83.4C5H9OH.Complexes of platinum(IV) are synthesized in a reaction of potassium-hexachloroplatinate(IV) with esters. Five novel platinum(IV) complexes are obtained: [PtCl4{(S,S)-iPr2eddip}], [PtCl4{(S,S)-iBu2eddip}], [PtCl4{(S,S)-cPe2eddip}], [PtCl4(iPr2eddp)] and [PtCl4(iBu2eddip)]. These complexes are characterized by elemental analysis, IR and NMR spectroscopy...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Хемијски факултетsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceУниверзитет у Београдуsr
dc.subjectplatina(IV) kompleksisr
dc.subjectplatinum(IV) complexesen
dc.subjectplatinum(II) complexesen
dc.subjectpalladium(II) complexesen
dc.subjectR2edda-type ligandsen
dc.subjectcrystal structureen
dc.subjectDFT calculationsen
dc.subjectantiproliferative activityen
dc.subjectplatina(II) kompleksisr
dc.subjectpaladijum(II) kompleksisr
dc.subjectR2edda ligandisr
dc.subjectkristalna strukturasr
dc.subjectDFT proračunisr
dc.subjectantiproliferativna aktivnostsr
dc.titleSinteza, karakterizacija i citotoksičnost kompleksa Pd(II), Pt(II) i Pt(IV) sa estrima R[sub]2edda-tipasr
dc.titleSynthesis, characterization and cytotoxity of Pd(II), Pt(II) and Pt(IV) complexes with R2edda-type estersen
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-ND
dcterms.abstractСабо, Тибор; Калуђеровић, Горан; Јуранић, Зорица; Гргурић-Шипка, Сања; Леовац, Вукадин; Змејковски, Бојана Б.; Синтеза, карактеризација и цитотоксичност комплекса Пд(ИИ), Пт(ИИ) и Пт(ИВ) са естрима Р[суб]2едда-типа; Синтеза, карактеризација и цитотоксичност комплекса Пд(ИИ), Пт(ИИ) и Пт(ИВ) са естрима Р[суб]2едда-типа;
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_3497
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs/bitstream/id/5849/Disertacija.pdf
dc.type.versionpublishedVersion


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