Приказ основних података о документу

dc.creatorFilipović, Vuk
dc.creatorNedeljkovic, Biljana D. Bozic
dc.creatorVukomanović, Marija
dc.creatorTomić, Simonida Lj.
dc.date.accessioned2019-01-30T18:00:31Z
dc.date.available2019-01-30T18:00:31Z
dc.date.issued2018
dc.identifier.issn0142-9418
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/2440
dc.description.abstractGelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized revealing that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers.en
dc.publisherElsevier Sci Ltd, Oxford
dc.relationSCOPES programme of the Swiss National Science Foundation
dc.relationSwiss Agency for Development and Cooperation - IZ73ZO_152327
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/176018/RS//
dc.rightsrestrictedAccess
dc.sourcePolymer Testing
dc.subjectHEMAen
dc.subjectPBAEen
dc.subjectBiocompatibleen
dc.subjectDegradableen
dc.subjectPorous scaffoldsen
dc.titleBiocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkersen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТомиц, Симонида Љ; Филиповић, Вук; Вукомановиц, Марија; Недељковиц, Биљана Д. Бозиц;
dc.citation.volume68
dc.citation.spage270
dc.citation.epage278
dc.citation.other68: 270-278
dc.citation.rankM21
dc.description.otherThe peer-reviewed version: [https://cer.ihtm.bg.ac.rs/handle/123456789/4293]
dc.identifier.doi10.1016/j.polymertesting.2018.04.024
dc.identifier.scopus2-s2.0-85046032696
dc.identifier.wos000437076000034
dc.type.versionpublishedVersion


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Приказ основних података о документу