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dc.creatorĐorđević, J.
dc.creatorKolarević, S.
dc.creatorJovanović, J.
dc.creatorKostić-Vuković, J.
dc.creatorNovaković, Irena
dc.creatorJeremić, M.
dc.creatorSladić, Dušan
dc.creatorVuković-Gačić, B.
dc.date.accessioned2019-01-30T18:00:03Z
dc.date.available2019-01-30T18:00:03Z
dc.date.issued2018
dc.identifier.issn0148-0545
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2415
dc.description.abstractTert-butylquinone (TBQ) and its alkylamino and aralkylamino derivatives are of high interest as a potential antitumor agent. Therefore, it was necessary to investigate if the compounds exert undesirable activities such as interaction with DNA molecule which could result in negative side effects in the case of their use in the diseases treatment. The major aim of this study was to investigate genotoxic potential of TBQ and selected derivatives in an acellular model by using plasmid DNA, in the prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002 and in eukaryotic models by using comet assay in human fetal lung cell line (MRC-5) and human liver cancer cell line (HepG2). Results indicated that in the acellular model TBQ and its derivatives do not interact with plasmid pUC19. In the prokaryotic model, only TBQ exerted weak genotoxic potential and only at highly cytotoxic concentrations. In eukaryotic models, genotoxic potential was detected mainly at the highest concentrations of the tested substances but the effect was lower in both cell lines in comparison with benzo[a]pyrene and etoposide which were used as positive controls. Weak genotoxic potential of tested compounds recommends them as good candidates for further testing in development of new antitumor agents.en
dc.publisherTaylor and Francis Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172058/RS//
dc.rightsrestrictedAccess
dc.sourceDrug and Chemical Toxicology
dc.subjectalkylamino and aralkylamino derivativesen
dc.subjectcomet assayen
dc.subjectgenotoxicityen
dc.subjectplasmid relaxationen
dc.subjectSOS/umuCen
dc.subjectTert-butylquinoneen
dc.titleEvaluation of genotoxic potential of tert-butylquinone and its derivatives in prokaryotic and eukaryotic test modelsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈовановић, Ј.; Новаковић, Ирена; Вуковић-Гачић, Б.; Сладић, Д.; Коларевић, С.; Ђорђевић, Ј.; Јеремић, М.; Костић-Вуковић, Ј.;
dc.citation.other
dc.citation.rankM22
dc.identifier.doi10.1080/01480545.2018.1514043
dc.identifier.rcubConv_4471
dc.identifier.scopus2-s2.0-85053908360
dc.type.versionpublishedVersion


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