Identification of NQO1 and ferrochelatase as interaction partners for neuroprotective N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides
Samo za registrovane korisnike
2018
Autori
Kostić Rajačić, SlađanaSchwall, Gerhard
Penjišević, Jelena
Andrić, Deana
Šukalović, Vladimir
Šoškić, Vukić
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Affinity chromatography was used to identify potential cellular targets that are responsible for neuroprotective activity of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides. Active and inactive representatives of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides bearing an extended linker were synthesized and immobilized on an agarose-based matrix. This was followed by the identification of specifically bound proteins isolated out of the whole rat brain extract. Inducible flavoprotein NAD(P)H:quinone oxidoreductase (NQO1) was identified as candidates for cellular targets.
Ključne reči:
arylpiperazines / ferrochelatase / neuroprotection / NQO1Izvor:
Chemical Biology & Drug Design, 2018, 92, 1, 1393-1397Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
DOI: 10.1111/cbdd.13193
ISSN: 1747-0277
PubMed: 29543381
WoS: 000436403500023
Scopus: 2-s2.0-85045070724
Institucija/grupa
IHTMTY - JOUR AU - Kostić Rajačić, Slađana AU - Schwall, Gerhard AU - Penjišević, Jelena AU - Andrić, Deana AU - Šukalović, Vladimir AU - Šoškić, Vukić PY - 2018 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2375 AB - Affinity chromatography was used to identify potential cellular targets that are responsible for neuroprotective activity of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides. Active and inactive representatives of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides bearing an extended linker were synthesized and immobilized on an agarose-based matrix. This was followed by the identification of specifically bound proteins isolated out of the whole rat brain extract. Inducible flavoprotein NAD(P)H:quinone oxidoreductase (NQO1) was identified as candidates for cellular targets. PB - Wiley, Hoboken T2 - Chemical Biology & Drug Design T1 - Identification of NQO1 and ferrochelatase as interaction partners for neuroprotective N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides VL - 92 IS - 1 SP - 1393 EP - 1397 DO - 10.1111/cbdd.13193 ER -
@article{ author = "Kostić Rajačić, Slađana and Schwall, Gerhard and Penjišević, Jelena and Andrić, Deana and Šukalović, Vladimir and Šoškić, Vukić", year = "2018", abstract = "Affinity chromatography was used to identify potential cellular targets that are responsible for neuroprotective activity of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides. Active and inactive representatives of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides bearing an extended linker were synthesized and immobilized on an agarose-based matrix. This was followed by the identification of specifically bound proteins isolated out of the whole rat brain extract. Inducible flavoprotein NAD(P)H:quinone oxidoreductase (NQO1) was identified as candidates for cellular targets.", publisher = "Wiley, Hoboken", journal = "Chemical Biology & Drug Design", title = "Identification of NQO1 and ferrochelatase as interaction partners for neuroprotective N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides", volume = "92", number = "1", pages = "1393-1397", doi = "10.1111/cbdd.13193" }
Kostić Rajačić, S., Schwall, G., Penjišević, J., Andrić, D., Šukalović, V.,& Šoškić, V.. (2018). Identification of NQO1 and ferrochelatase as interaction partners for neuroprotective N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides. in Chemical Biology & Drug Design Wiley, Hoboken., 92(1), 1393-1397. https://doi.org/10.1111/cbdd.13193
Kostić Rajačić S, Schwall G, Penjišević J, Andrić D, Šukalović V, Šoškić V. Identification of NQO1 and ferrochelatase as interaction partners for neuroprotective N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides. in Chemical Biology & Drug Design. 2018;92(1):1393-1397. doi:10.1111/cbdd.13193 .
Kostić Rajačić, Slađana, Schwall, Gerhard, Penjišević, Jelena, Andrić, Deana, Šukalović, Vladimir, Šoškić, Vukić, "Identification of NQO1 and ferrochelatase as interaction partners for neuroprotective N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides" in Chemical Biology & Drug Design, 92, no. 1 (2018):1393-1397, https://doi.org/10.1111/cbdd.13193 . .