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dc.creatorJeremic, Marko
dc.creatorDinic, Jelena
dc.creatorPesic, Milica
dc.creatorStepanovic, Marija
dc.creatorNovaković, Irena
dc.creatorSegan, Dejan
dc.creatorSladić, Dušan
dc.date.accessioned2019-01-30T17:58:53Z
dc.date.available2019-01-30T17:58:53Z
dc.date.issued2018
dc.identifier.issn0352-5139
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2361
dc.description.abstractIn this paper, the synthesis of fourteen alkylamino and arylamino derivatives of sesquiterpene quinone avarone and its model compound tert-butylquinone is described. Branched, cyclic, allylic and benzylic alkylamino/arylamino groups were introduced into the quinone moiety. For all the obtained derivatives, their biological activity and redox properties were studied. The cytotoxic activity of the synthesized derivatives towards multidrug resistant (MDR) human non-small cell lung carcinoma NCI-H460/R cells, their sensitive counterpart NCI-H460 and human normal keratinocytes (HaCaT) was investigated. The antimicrobial activity towards Gram-positive and Gram-negative bacteria, and fungal cultures was determined. Some of the synthesized derivatives showed selectivity for cancer cells, including MDR cells. Regarding their cell death induction potential, the most promising compounds were allylamino derivatives, preferentially triggering apoptosis, with high selectivity for cancer cells, including MDR cells. Several compounds showed promising antimicrobial activity, comparable to those of commercial antibiotic and antimycotic agents.en
dc.publisherSerbian Chemical Society
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS//
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectquinonesen
dc.subjectanticancer activityen
dc.subjectmultidrug resistanten
dc.subjectapoptosisen
dc.subjectantimicrobial activityen
dc.subjectcyclic voltammetryen
dc.titleAlkylamino and aralkylamino derivatives of avarone and its mimetic as selective agents against non-small cell lung cancer cells, their antibacterial and antifungal potentialen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractЈеремиц, Марко; Степановиц, Марија; Сладиц, Дусан; Диниц, Јелена; Новаковић, Ирена; Сеган, Дејан; Песиц, Милица;
dc.citation.volume83
dc.citation.issue11
dc.citation.spage1193
dc.citation.epage1207
dc.citation.other83(11): 1193-1207
dc.citation.rankM23
dc.identifier.doi10.2298/JSC180627062J
dc.identifier.rcubConv_4029
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8745/2359.pdf
dc.identifier.scopus2-s2.0-85053920097
dc.identifier.wos000452167500001
dc.type.versionpublishedVersion


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