Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis
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2018
Authors
Krstić, GordanaJadranin, Milka
Todorović, Nina
Pešić, Milica
Stankovic, Tijana
Aljančić, Ivana
Tešević, Vele
Article (Published version)
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Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectro-scopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/12 and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.
Keywords:
Euphorbia nicaeensis / Euphorbiaceae / Diterpenoids / Jatrophanes / Isolation / Structutre determination / P-glycoprotein / Multi-drug resistanceSource:
Phytochemistry, 2018, 148, 104-112Publisher:
- Oxford : Pergamon-Elsevier Science Ltd
Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-MESTD-Basic Research (BR or ON)-172053)
- Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41031)
DOI: 10.1016/j.phytochem.2018.01.016
ISSN: 0031-9422
PubMed: 29421506
WoS: 000427334600013
Scopus: 2-s2.0-85041594265
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IHTMTY - JOUR AU - Krstić, Gordana AU - Jadranin, Milka AU - Todorović, Nina AU - Pešić, Milica AU - Stankovic, Tijana AU - Aljančić, Ivana AU - Tešević, Vele PY - 2018 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2319 AB - Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectro-scopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/12 and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER. PB - Oxford : Pergamon-Elsevier Science Ltd T2 - Phytochemistry T1 - Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis VL - 148 SP - 104 EP - 112 DO - 10.1016/j.phytochem.2018.01.016 ER -
@article{ author = "Krstić, Gordana and Jadranin, Milka and Todorović, Nina and Pešić, Milica and Stankovic, Tijana and Aljančić, Ivana and Tešević, Vele", year = "2018", abstract = "Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectro-scopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/12 and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.", publisher = "Oxford : Pergamon-Elsevier Science Ltd", journal = "Phytochemistry", title = "Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis", volume = "148", pages = "104-112", doi = "10.1016/j.phytochem.2018.01.016" }
Krstić, G., Jadranin, M., Todorović, N., Pešić, M., Stankovic, T., Aljančić, I.,& Tešević, V.. (2018). Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis. in Phytochemistry Oxford : Pergamon-Elsevier Science Ltd., 148, 104-112. https://doi.org/10.1016/j.phytochem.2018.01.016
Krstić G, Jadranin M, Todorović N, Pešić M, Stankovic T, Aljančić I, Tešević V. Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis. in Phytochemistry. 2018;148:104-112. doi:10.1016/j.phytochem.2018.01.016 .
Krstić, Gordana, Jadranin, Milka, Todorović, Nina, Pešić, Milica, Stankovic, Tijana, Aljančić, Ivana, Tešević, Vele, "Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis" in Phytochemistry, 148 (2018):104-112, https://doi.org/10.1016/j.phytochem.2018.01.016 . .