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dc.creatorMilovanovic, Petar
dc.creatorVuković, Zorica
dc.creatorAntonijevic, Djordje
dc.creatorDjonic, Danijela
dc.creatorZivkovic, Vladimir
dc.creatorNikolic, Slobodan
dc.creatorDjuric, Marija
dc.date.accessioned2019-01-30T17:56:48Z
dc.date.available2019-01-30T17:56:48Z
dc.date.issued2017
dc.identifier.issn0957-4530
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2263
dc.description.abstractBone is a remarkable biological nanocomposite material showing peculiar hierarchical organization from smaller (nano, micro) to larger (macro) length scales. Increased material porosity is considered as the main feature of fragile bone at larger length-scales. However, there is a shortage of quantitative information on bone porosity at smaller length-scales, as well as on the distribution of pore sizes in healthy vs. fragile bone. Therefore, here we investigated how healthy and fragile bones differ in pore volume and pore size distribution patterns, considering a wide range of mostly neglected pore sizes from nano to micron-length scales (7.5 to 15000 nm). Cortical bone specimens from four young healthy women (age: 35 +/- 6 years) and five women with bone fracture (age: 82 +/- 5 years) were analyzed by mercury porosimetry. Our findings showed that, surprisingly, fragile bone demonstrated lower pore volume at the measured scales. Furtnermore, pore size distribution showed differential patterns between healthy and fragile bones, where healthy bone showed especially high proportion of pores between 200 and 15000 nm. Therefore, although fragile bones are known for increased porosity at macroscopic level and level of tens or hundreds of microns as firmly established in the literature, our study with a unique assessment range of nano-to micron-sized pores reveal that osteoporosis does not imply increased porosity at all length scales. Our thorough assessment of bone porosity reveals a specific distribution of porosities at smaller length-scales and contributes to proper understanding of bone structure which is important for designing new biomimetic bone substitute materials. [GRAPHICS]en
dc.publisherSpringer, Dordrecht
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45005/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45001/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Materials Science-Materials in Medicine
dc.titlePorotic paradox: distribution of cortical bone pore sizes at nano- and micro-levels in healthy vs. fragile human boneen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЗивковиц, Владимир; Дјуриц, Марија; Миловановиц, Петар; Николиц, Слободан; Дјониц, Данијела; Aнтонијевиц, Дјордје; Вуковић, Зорица;
dc.citation.volume28
dc.citation.issue5
dc.citation.other28(5):
dc.citation.rankM22
dc.identifier.pmid28357689
dc.identifier.doi10.1007/s10856-017-5878-7
dc.identifier.rcubConv_3720
dc.identifier.scopus2-s2.0-85016556145
dc.identifier.wos000401003300008
dc.type.versionpublishedVersion


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