Porotic paradox: distribution of cortical bone pore sizes at nano- and micro-levels in healthy vs. fragile human bone
Само за регистроване кориснике
2017
Аутори
Milovanovic, PetarVuković, Zorica
Antonijevic, Djordje
Djonic, Danijela
Zivkovic, Vladimir
Nikolic, Slobodan
Djuric, Marija
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Bone is a remarkable biological nanocomposite material showing peculiar hierarchical organization from smaller (nano, micro) to larger (macro) length scales. Increased material porosity is considered as the main feature of fragile bone at larger length-scales. However, there is a shortage of quantitative information on bone porosity at smaller length-scales, as well as on the distribution of pore sizes in healthy vs. fragile bone. Therefore, here we investigated how healthy and fragile bones differ in pore volume and pore size distribution patterns, considering a wide range of mostly neglected pore sizes from nano to micron-length scales (7.5 to 15000 nm). Cortical bone specimens from four young healthy women (age: 35 +/- 6 years) and five women with bone fracture (age: 82 +/- 5 years) were analyzed by mercury porosimetry. Our findings showed that, surprisingly, fragile bone demonstrated lower pore volume at the measured scales. Furtnermore, pore size distribution showed differential p...atterns between healthy and fragile bones, where healthy bone showed especially high proportion of pores between 200 and 15000 nm. Therefore, although fragile bones are known for increased porosity at macroscopic level and level of tens or hundreds of microns as firmly established in the literature, our study with a unique assessment range of nano-to micron-sized pores reveal that osteoporosis does not imply increased porosity at all length scales. Our thorough assessment of bone porosity reveals a specific distribution of porosities at smaller length-scales and contributes to proper understanding of bone structure which is important for designing new biomimetic bone substitute materials. [GRAPHICS]
Извор:
Journal of Materials Science-Materials in Medicine, 2017, 28, 5Издавач:
- Springer, Dordrecht
Финансирање / пројекти:
- Функционални, функционализовани и усавршени нано материјали (RS-45005)
- Наноструктурни функционални и композитни материјали у каталитичким и сорпционим процесима (RS-45001)
DOI: 10.1007/s10856-017-5878-7
ISSN: 0957-4530
PubMed: 28357689
WoS: 000401003300008
Scopus: 2-s2.0-85016556145
Институција/група
IHTMTY - JOUR AU - Milovanovic, Petar AU - Vuković, Zorica AU - Antonijevic, Djordje AU - Djonic, Danijela AU - Zivkovic, Vladimir AU - Nikolic, Slobodan AU - Djuric, Marija PY - 2017 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2263 AB - Bone is a remarkable biological nanocomposite material showing peculiar hierarchical organization from smaller (nano, micro) to larger (macro) length scales. Increased material porosity is considered as the main feature of fragile bone at larger length-scales. However, there is a shortage of quantitative information on bone porosity at smaller length-scales, as well as on the distribution of pore sizes in healthy vs. fragile bone. Therefore, here we investigated how healthy and fragile bones differ in pore volume and pore size distribution patterns, considering a wide range of mostly neglected pore sizes from nano to micron-length scales (7.5 to 15000 nm). Cortical bone specimens from four young healthy women (age: 35 +/- 6 years) and five women with bone fracture (age: 82 +/- 5 years) were analyzed by mercury porosimetry. Our findings showed that, surprisingly, fragile bone demonstrated lower pore volume at the measured scales. Furtnermore, pore size distribution showed differential patterns between healthy and fragile bones, where healthy bone showed especially high proportion of pores between 200 and 15000 nm. Therefore, although fragile bones are known for increased porosity at macroscopic level and level of tens or hundreds of microns as firmly established in the literature, our study with a unique assessment range of nano-to micron-sized pores reveal that osteoporosis does not imply increased porosity at all length scales. Our thorough assessment of bone porosity reveals a specific distribution of porosities at smaller length-scales and contributes to proper understanding of bone structure which is important for designing new biomimetic bone substitute materials. [GRAPHICS] PB - Springer, Dordrecht T2 - Journal of Materials Science-Materials in Medicine T1 - Porotic paradox: distribution of cortical bone pore sizes at nano- and micro-levels in healthy vs. fragile human bone VL - 28 IS - 5 DO - 10.1007/s10856-017-5878-7 ER -
@article{ author = "Milovanovic, Petar and Vuković, Zorica and Antonijevic, Djordje and Djonic, Danijela and Zivkovic, Vladimir and Nikolic, Slobodan and Djuric, Marija", year = "2017", abstract = "Bone is a remarkable biological nanocomposite material showing peculiar hierarchical organization from smaller (nano, micro) to larger (macro) length scales. Increased material porosity is considered as the main feature of fragile bone at larger length-scales. However, there is a shortage of quantitative information on bone porosity at smaller length-scales, as well as on the distribution of pore sizes in healthy vs. fragile bone. Therefore, here we investigated how healthy and fragile bones differ in pore volume and pore size distribution patterns, considering a wide range of mostly neglected pore sizes from nano to micron-length scales (7.5 to 15000 nm). Cortical bone specimens from four young healthy women (age: 35 +/- 6 years) and five women with bone fracture (age: 82 +/- 5 years) were analyzed by mercury porosimetry. Our findings showed that, surprisingly, fragile bone demonstrated lower pore volume at the measured scales. Furtnermore, pore size distribution showed differential patterns between healthy and fragile bones, where healthy bone showed especially high proportion of pores between 200 and 15000 nm. Therefore, although fragile bones are known for increased porosity at macroscopic level and level of tens or hundreds of microns as firmly established in the literature, our study with a unique assessment range of nano-to micron-sized pores reveal that osteoporosis does not imply increased porosity at all length scales. Our thorough assessment of bone porosity reveals a specific distribution of porosities at smaller length-scales and contributes to proper understanding of bone structure which is important for designing new biomimetic bone substitute materials. [GRAPHICS]", publisher = "Springer, Dordrecht", journal = "Journal of Materials Science-Materials in Medicine", title = "Porotic paradox: distribution of cortical bone pore sizes at nano- and micro-levels in healthy vs. fragile human bone", volume = "28", number = "5", doi = "10.1007/s10856-017-5878-7" }
Milovanovic, P., Vuković, Z., Antonijevic, D., Djonic, D., Zivkovic, V., Nikolic, S.,& Djuric, M.. (2017). Porotic paradox: distribution of cortical bone pore sizes at nano- and micro-levels in healthy vs. fragile human bone. in Journal of Materials Science-Materials in Medicine Springer, Dordrecht., 28(5). https://doi.org/10.1007/s10856-017-5878-7
Milovanovic P, Vuković Z, Antonijevic D, Djonic D, Zivkovic V, Nikolic S, Djuric M. Porotic paradox: distribution of cortical bone pore sizes at nano- and micro-levels in healthy vs. fragile human bone. in Journal of Materials Science-Materials in Medicine. 2017;28(5). doi:10.1007/s10856-017-5878-7 .
Milovanovic, Petar, Vuković, Zorica, Antonijevic, Djordje, Djonic, Danijela, Zivkovic, Vladimir, Nikolic, Slobodan, Djuric, Marija, "Porotic paradox: distribution of cortical bone pore sizes at nano- and micro-levels in healthy vs. fragile human bone" in Journal of Materials Science-Materials in Medicine, 28, no. 5 (2017), https://doi.org/10.1007/s10856-017-5878-7 . .