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dc.creatorNovaković, Miroslav
dc.creatorNikodinović-Runić, Jasmina
dc.creatorVeselinovic, Jovana
dc.creatorIlić-Tomić, Tatjana
dc.creatorVidaković, Vera
dc.creatorTešević, Vele
dc.creatorMilosavljević, Slobodan
dc.date.accessioned2019-01-30T17:56:14Z
dc.date.available2019-01-30T17:56:14Z
dc.date.issued2017
dc.identifier.issn0163-3864
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2237
dc.description.abstractSeven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of canter cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and Ha for an in silico investigation.en
dc.publisherAmer Chemical Soc, Washington
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173048/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Natural Products
dc.titleBioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Barken
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНоваковић, Мирослав; Веселиновиц, Јована; Милосављевиц, Слободан; Илиц-Томиц, Татјана; Никодиновиц-Руниц, Јасмина; Видаковиц, Вера; Тесевиц, Веле;
dc.citation.volume80
dc.citation.issue5
dc.citation.spage1255
dc.citation.epage1263
dc.citation.other80(5): 1255-1263
dc.citation.rankaM21
dc.identifier.pmid28368586
dc.identifier.doi10.1021/acs.jnatprod.6b00805
dc.identifier.rcubConv_3733
dc.identifier.scopus2-s2.0-85019767389
dc.identifier.wos000402498300004
dc.type.versionpublishedVersion


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