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dc.creatorPantelić, N.
dc.creatorStanojković, Tatjana
dc.creatorZmejkovski, Bojana
dc.creatorKaluđerović, Goran N.
dc.creatorSabo, T.J.
dc.date.accessioned2019-01-30T17:55:37Z
dc.date.available2019-01-30T17:55:37Z
dc.date.issued2017
dc.identifier.issn1820-8665
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2205
dc.description.abstractSix gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N’-diacetate, general formula [AuCl2{(S,S)-R2eddch}]PF6, [(S,S)-eddch = (S,S)-ethylenediamine-N,N’-di-2-(3-cyclohexyl)propanoate, R = Me, Et, n-Pr, n-Bu, i-Bu, i-Am, 1-6, respectively], were tested against cancer cell lines such as human melanoma Fem-x, human colon carcinoma LS174T and non-small cell lung carcinoma A549 as well as a non-cancerous human embryonic lung fibroblasts MRC-5 using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay with the aim of assessing in vitro antitumoral activity and selectivity. All investigated complexes showed lower cytotoxicity and better or similar selectivity in comparison to cisplatin, used as reference compound. Complex [AuCl2{(S,S)-(i-Am)2eddch}]PF6 (6) demonstrated the highest activity against Fem-x (IC50 = 14.98 ± 0.34 µM). Additionally, the same complex expressed 4.5 times higher selectivity than cisplatin.en
dc.publisherMedicinski fakultet, Kragujevac
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.rightsopenAccess
dc.sourceSerbian Journal of Experimental and Clinical Research
dc.subjectCytotoxicityen
dc.subjectGold(iii) complexesen
dc.subjectR2edda type-ligandsen
dc.subjectSelectivityen
dc.titleAntiproliferative activity of gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N’-diacetate [Antiproliferativna aktivnost zlato(III) kompleksa sa cikloheksil-funkcionalizovanim estrima etilendiamin-N,N’-diacetata]en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСабо, Т.Ј.; Змејковски, Бојана; Станојковић, Т.П.; Пантелић, Н.; Калуђеровић, Г.Н.;
dc.citation.volume18
dc.citation.issue4
dc.citation.spage289
dc.citation.epage294
dc.citation.other18(4): 289-294
dc.citation.rankM51
dc.identifier.doi10.1515/SJECR-2017-0067
dc.identifier.rcubConv_4449
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8613/2203.pdf
dc.identifier.scopus2-s2.0-85044138936
dc.type.versionpublishedVersion


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