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dc.creatorFilipovic, Nenad R.
dc.creatorBjelogrlić, Snežana K.
dc.creatorTodorović, Tamara
dc.creatorBlagojević, Vladimir A.
dc.creatorMuller, Christian D.
dc.creatorMarinković, Aleksandar D.
dc.creatorVujčić, Miroslava
dc.creatorJanović, Barbara
dc.creatorMalešević, Aleksandar S.
dc.creatorBegovic, Nebojsa
dc.creatorSenćanski, Milan
dc.creatorMinić, Dragica M.
dc.date.accessioned2019-01-30T17:51:31Z
dc.date.available2019-01-30T17:51:31Z
dc.date.issued2016
dc.identifier.issn2046-2069
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/2010
dc.description.abstractA new Ni(II) complex, [Ni(L)(H2O)] (1), with diethyl 3,3'-(2,2'-(1,1'-(pyridine-2,6-diyl) bis(ethan-1-yl-1-ylidene)) bis(hydrazin-1-yl-2-ylidene)) bis(3-oxopropanoate) ligand (H2L) was synthesized as a potential chemotherapeutic agent. Polidentate ligand was coordinated to Ni(II) NNN-tridentately, in dianionic form, while monodentate water coordination completed square-planar geometry around metal. Structure in the solution was determined by NMR spectroscopy and the same coordination mode was observed in the solid state using IR spectroscopy and further verified by DFT calculations and electrochemical studies. Thermal stability of 1 was determined in both air and nitrogen atmosphere. Anticancer activity of 1 was investigated on acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma (AsPC-1) cell lines. On THP-1 cells 1 induced powerful apoptotic response (ED50 = 10 +/- 3 mu M), which was revealed to be only partially caspase-dependent, with activation of caspase-8 as the dominant course. This suggested that experimentally validated covalent binding of 1 to DNA is not the only mechanism responsible for programmed cell death. This was supported with experiments on AsPC-1 cells. Although treatment of those cells with 1 resulted in poor apoptotic response, cell cycle changes showed concentration-dependent shifts indicating a dual mechanism of activity. This study also reviews the results of preliminary biological screening, which demonstrates that 1 displays a unique pattern of anticancer activity with at least two mechanisms involved.en
dc.publisherRoyal Soc Chemistry, Cambridge
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172057/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceRSC Advances
dc.titleNi(II) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell linesen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractВујчић, Мирослава; Минић, Драгица М.; Малесевиц, Aлександар С.; Благојевиц, Владимир A.; Беговиц, Небојса; Бјелогрлић, Снежана К.; Филиповиц, Ненад Р.; Муллер, Цхристиан Д.; Маринковиц, Aлександар; Јановић, Барбара; Сенцански, Милан; Тодоровиц, Тамара Р.;
dc.citation.volume6
dc.citation.issue110
dc.citation.spage108726
dc.citation.epage108740
dc.citation.other6(110): 108726-108740
dc.citation.rankM22
dc.identifier.doi10.1039/c6ra24604d
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs//bitstream/id/8441/2008.pdf
dc.identifier.scopus2-s2.0-84997501324
dc.identifier.wos000389342800068
dc.type.versionpublishedVersion


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Приказ основних података о документу