Electrochemical properties of some gold(III) complexes with (S,S)-R(2)edda-type ligands
Апстракт
Oxidation-reduction properties of eleven gold(III) complexes with (S,S)-R(2)edda-type ligands was studied by cyclic and differential pulse voltammetry in DMSO. Series I: [AuCl2{(S,S)-R(2)eddip}]PF6, (S,S)-eddip = (S,S)-ethylenediamine-N,N'-di-2-propanoate, R = n-butyl, n-pentyl, isobutyl, isoamyl, cyclopentyl, 1-5; II: [AuCl2{(S,S)-R(2)eddch}]PF6, (S,S)-eddch = (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate, R = methyl, ethyl, n-propyl, n-butyl, isobutyl, isoamyl, 6-11. Voltammograms in DMSO showed two successive irreversible reduction steps, where Au-I species were the final reduction product. Reduction potential values are in range from 116 to 156 mV (Ep(1)) and -520 to -572 mV (Ep(2)) for Series I and from 148 to 228 mV (Ep(1)) and -569 to -638 mV (Ep(2)) for Series II. In general, slightly easier reduction of complexes belonging to Series I (higher cytotoxicity) could be due to less steric hindrance around the gold center. Reduction potentials and anticancer activity are ...not in correlation.
Кључне речи:
gold(III) complexes / R(2)edda-type ligands / anticancer activity / reduction potential / voltammetryИзвор:
International Journal of Electrochemical Science, 2016, 11, 2, 1162-1171Издавач:
- Esg, Belgrade
Финансирање / пројекти:
- Рационални дизајн и синтеза биолошки активних и координационих једињења и функционалних материјала, релевантних у (био)нанотехнологији (RS-MESTD-Basic Research (BR or ON)-172035)
- Примена унапређених оксидационих процеса и наноструктурисаних оксидних материјала за уклањање загађивача из животне средине, развој и оптимизација инструменталних техника за праћење ефикасности (RS-MESTD-Basic Research (BR or ON)-172030)
Институција/група
IHTMTY - JOUR AU - Pantelic, Nebojsa AU - Stanković, Dalibor AU - Zmejkovski, Bojana AU - Kaluđerović, Goran N. AU - Sabo, Tibor PY - 2016 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1963 AB - Oxidation-reduction properties of eleven gold(III) complexes with (S,S)-R(2)edda-type ligands was studied by cyclic and differential pulse voltammetry in DMSO. Series I: [AuCl2{(S,S)-R(2)eddip}]PF6, (S,S)-eddip = (S,S)-ethylenediamine-N,N'-di-2-propanoate, R = n-butyl, n-pentyl, isobutyl, isoamyl, cyclopentyl, 1-5; II: [AuCl2{(S,S)-R(2)eddch}]PF6, (S,S)-eddch = (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate, R = methyl, ethyl, n-propyl, n-butyl, isobutyl, isoamyl, 6-11. Voltammograms in DMSO showed two successive irreversible reduction steps, where Au-I species were the final reduction product. Reduction potential values are in range from 116 to 156 mV (Ep(1)) and -520 to -572 mV (Ep(2)) for Series I and from 148 to 228 mV (Ep(1)) and -569 to -638 mV (Ep(2)) for Series II. In general, slightly easier reduction of complexes belonging to Series I (higher cytotoxicity) could be due to less steric hindrance around the gold center. Reduction potentials and anticancer activity are not in correlation. PB - Esg, Belgrade T2 - International Journal of Electrochemical Science T1 - Electrochemical properties of some gold(III) complexes with (S,S)-R(2)edda-type ligands VL - 11 IS - 2 SP - 1162 EP - 1171 UR - https://hdl.handle.net/21.15107/rcub_cherry_2060 ER -
@article{ author = "Pantelic, Nebojsa and Stanković, Dalibor and Zmejkovski, Bojana and Kaluđerović, Goran N. and Sabo, Tibor", year = "2016", abstract = "Oxidation-reduction properties of eleven gold(III) complexes with (S,S)-R(2)edda-type ligands was studied by cyclic and differential pulse voltammetry in DMSO. Series I: [AuCl2{(S,S)-R(2)eddip}]PF6, (S,S)-eddip = (S,S)-ethylenediamine-N,N'-di-2-propanoate, R = n-butyl, n-pentyl, isobutyl, isoamyl, cyclopentyl, 1-5; II: [AuCl2{(S,S)-R(2)eddch}]PF6, (S,S)-eddch = (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate, R = methyl, ethyl, n-propyl, n-butyl, isobutyl, isoamyl, 6-11. Voltammograms in DMSO showed two successive irreversible reduction steps, where Au-I species were the final reduction product. Reduction potential values are in range from 116 to 156 mV (Ep(1)) and -520 to -572 mV (Ep(2)) for Series I and from 148 to 228 mV (Ep(1)) and -569 to -638 mV (Ep(2)) for Series II. In general, slightly easier reduction of complexes belonging to Series I (higher cytotoxicity) could be due to less steric hindrance around the gold center. Reduction potentials and anticancer activity are not in correlation.", publisher = "Esg, Belgrade", journal = "International Journal of Electrochemical Science", title = "Electrochemical properties of some gold(III) complexes with (S,S)-R(2)edda-type ligands", volume = "11", number = "2", pages = "1162-1171", url = "https://hdl.handle.net/21.15107/rcub_cherry_2060" }
Pantelic, N., Stanković, D., Zmejkovski, B., Kaluđerović, G. N.,& Sabo, T.. (2016). Electrochemical properties of some gold(III) complexes with (S,S)-R(2)edda-type ligands. in International Journal of Electrochemical Science Esg, Belgrade., 11(2), 1162-1171. https://hdl.handle.net/21.15107/rcub_cherry_2060
Pantelic N, Stanković D, Zmejkovski B, Kaluđerović GN, Sabo T. Electrochemical properties of some gold(III) complexes with (S,S)-R(2)edda-type ligands. in International Journal of Electrochemical Science. 2016;11(2):1162-1171. https://hdl.handle.net/21.15107/rcub_cherry_2060 .
Pantelic, Nebojsa, Stanković, Dalibor, Zmejkovski, Bojana, Kaluđerović, Goran N., Sabo, Tibor, "Electrochemical properties of some gold(III) complexes with (S,S)-R(2)edda-type ligands" in International Journal of Electrochemical Science, 11, no. 2 (2016):1162-1171, https://hdl.handle.net/21.15107/rcub_cherry_2060 .