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dc.creatorDamjanovic, Ana
dc.creatorZdunic, Gordana
dc.creatorSavikin, Katarina
dc.creatorMandić, Boris
dc.creatorJadranin, Milka
dc.creatorMatić, Ivana Z.
dc.creatorStanojković, Tatjana
dc.date.accessioned2019-01-30T17:49:17Z
dc.date.available2019-01-30T17:49:17Z
dc.date.issued2016
dc.identifier.issn1991-007X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1901
dc.description.abstractThe cytotoxicity of Mahonia aquifolium ethanol and water extracts was examined using MTT test. The morphological changes were analyzed by fluorescence microscopy. Cell cycle distribution and possible activation of caspase-dependent pathway of cell death were assessed by flow cytometry. The effects of ethanol and water extracts on migration of endothelial EA. hy926 cells were analyzed by in vitro scratch assay and inhibition of angiogenesis was detected using tube formation assay. Both extracts demonstrated cytotoxic effects on cancer cell lines with very high selectivity. Morphological evaluation indicated apoptosis. These results were confirmed with cell cycle analysis, where there was accumulation of cancer cells in the subG1 phase. Ethanol and water extracts induced a caspase-dependent apoptosis in HeLa cells through activation of caspase-3 and caspase-8. Both extracts showed the ability to inbibit the migration of EA. hy926 cells and initial steps of angiogenesis. In addition, ethanol extract exerted significant anti-angiogenic effect.en
dc.publisherBangladesh Pharmacological Soc, Shahbah
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.rightsopenAccess
dc.sourceBangladesh Journal of Pharmacology
dc.titleEvaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesisen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractМатиц, Ивана З.; Дамјановиц, Aна; Здуниц, Гордана; Јадранин, Милка; Мандиц, Борис; Станојковиц, Татјана П.; Савикин, Катарина;
dc.citation.volume11
dc.citation.issue3
dc.citation.spage741
dc.citation.epage749
dc.citation.other11(3): 741-749
dc.citation.rankM23
dc.identifier.doi10.3329/bjp.v11i3.27103
dc.identifier.rcubConv_3646
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8337/1899.pdf
dc.identifier.scopus2-s2.0-84989813691
dc.identifier.wos000390318200027
dc.type.versionpublishedVersion


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