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Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design
dc.creator | Isailovic, Tanja | |
dc.creator | Dordevic, Sanela | |
dc.creator | Marković, Bojan D. | |
dc.creator | Randjelović, Danijela | |
dc.creator | Cekic, Nebojsa | |
dc.creator | Lukić, Milica | |
dc.creator | Pantelić, Ivana | |
dc.creator | Daniels, Rolf | |
dc.creator | Savić, Snežana D. | |
dc.date.accessioned | 2019-01-30T17:48:12Z | |
dc.date.available | 2019-01-30T17:48:12Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0022-3549 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/1846 | |
dc.description.abstract | We aimed to develop lecithin-based nanoemulsions intended for effective aceclofenac (ACF) skin delivery utilizing sucrose esters [sucrose palmitate (SP) and sucrose stearate (SS)] as additional stabilizers and penetration enhancers. To find the suitable surfactant mixtures and levels of process variables (homogenization pressure and number of cycles-high pressure homogenization manufacturing method) that result in drug-loaded nanoemulsions with minimal droplet size and narrow size distribution, a combined mixture-process experimental design was employed. Based on optimization data, selected nanoemulsions were evaluated regarding morphology, surface charge, drug-excipient interactions, physical stability, and in vivo skin performances (skin penetration and irritation potential). The predicted physicochemical properties and storage stability were proved satisfying for ACF-loaded nanoemulsions containing 2% of SP in the blend with 0%-1% of SS and 1%-2% of egg lecithin (produced at 50 degrees C/20 cycles/800 bar). Additionally, the in vivo tape stripping demonstrated superior ACF skin absorption from these nanoemulsions, particularly from those containing 2% of SP, 0.5% of SS, and 1.5% of egg lecithin, when comparing with the sample costabilized by conventional surfactant-polysorbate 80. In summary, the combined mixture-process experimental design was shown as a feasible tool for formulation development of multisurfactant-based nanosized delivery systems with potentially improved overall product performances. | en |
dc.publisher | Wiley, Hoboken | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/32008/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Pharmaceutical Sciences | |
dc.subject | nanotechnology | en |
dc.subject | sucrose esters | en |
dc.subject | phospholipids | en |
dc.subject | solubility | en |
dc.subject | experimental design | en |
dc.subject | physicochemical properties | en |
dc.subject | drug-excipient interaction | en |
dc.subject | physical stability | en |
dc.subject | tape stripping | en |
dc.subject | skin irritation potential | en |
dc.title | Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Исаиловиц, Тања; Даниелс, Ролф; Цекиц, Небојса; Ранђеловић, Данијела; Дордевиц, Санела; Марковиц, Бојан; Лукиц, Милица; Пантелиц, Ивана; Савиц, Снезана; | |
dc.citation.volume | 105 | |
dc.citation.issue | 1 | |
dc.citation.spage | 308 | |
dc.citation.epage | 323 | |
dc.citation.other | 105(1): 308-323 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 26539935 | |
dc.identifier.doi | 10.1002/jps.24706 | |
dc.identifier.scopus | 2-s2.0-84964478863 | |
dc.identifier.wos | 000381768000038 | |
dc.type.version | publishedVersion |