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Heteropentanuclear Oxalato-Bridged nd-4f (n=4, 5) Metal Complexes with NO Ligand: Synthesis, Crystal Structures, Aqueous Stability and Antiproliferative Activity
dc.creator | Kuhn, Paul-Steffen | |
dc.creator | Cremer, Laura | |
dc.creator | Gavriluta, Anatolie | |
dc.creator | Jovanovic, Katarina K | |
dc.creator | Filipovic, Lana | |
dc.creator | Hummer, Alfred A | |
dc.creator | Buechel, Gabriel E | |
dc.creator | Dojčinović, Biljana | |
dc.creator | Meier, Samuel M | |
dc.creator | Rompel, Annette | |
dc.creator | Radulovic, Sinisa | |
dc.creator | Tommasino, Jean Bernard | |
dc.creator | Luneau, Dominique | |
dc.creator | Arion, Vladimir B | |
dc.date.accessioned | 2019-01-30T17:44:41Z | |
dc.date.available | 2019-01-30T17:44:41Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0947-6539 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/1680 | |
dc.description.abstract | A series of heteropentanuclear oxalate-bridged Ru(NO)-Ln (4d-4f) metal complexes of the general formula (nBu(4)N)(5)[Ln{RuCl3(-ox)(NO)}(4)], where Ln=Y (2), Gd (3), Tb (4), Dy (5) and ox=oxalate anion, were obtained by treatment of (nBu(4)N)(2)[RuCl3(ox)(NO)] (1) with the respective lanthanide salt in 4:1 molar ratio. The compounds were characterized by elemental analysis, IR spectroscopy, electrospray ionization (ESI) mass spectrometry, while 1, 2, and 5 were in addition analyzed by X-ray crystallography, 1 by Ru K-edge XAS and 1 and 2 by (CNMR)-C-13 spectroscopy. X-ray diffraction showed that in 2 and 5 four complex anions [RuCl3(ox)(NO)](2-) are coordinated to Y-III and Dy-III, respectively, with formation of [Ln{RuCl3(-ox)(NO)}(4)](5-) (Ln=Y, Dy). While Y-III is eight-coordinate in 2, Dy-III is nine-coordinate in 5, with an additional coordination of an EtOH molecule. The negative charge is counterbalanced by five nBu(4)N(+) ions present in the crystal structure. The stability of complexes 2 and 5 in aqueous medium was monitored by UV/Vis spectroscopy. The antiproliferative activity of ruthenium-lanthanide complexes 2-5 were assayed in two human cancer cell lines (HeLa and A549) and in a noncancerous cell line (MRC-5) and compared with those obtained for the previously reported Os(NO)-Ln (5d-4f) analogues (nBu(4)N)(5)[Ln{OsCl3(ox)(NO)}(4)] (Ln=Y (6), Gd (7), Tb (8), Dy (9)). Complexes 2-5 were found to be slightly more active than 1 in inhibiting the proliferation of HeLa and A549 cells, and significantly more cytotoxic than 5d-4f metal complexes 6-9 in terms of IC50 values. The highest antiproliferative activity with IC50 values of 20.0 and 22.4M was found for 4 in HeLa and A549 cell lines, respectively. These cytotoxicity results are in accord with the presented ICP-MS data, indicating five- to eightfold greater accumulation of ruthenium versus osmium in human A549 cancer cells. | en |
dc.publisher | Wiley-V C H Verlag Gmbh, Weinheim | |
dc.relation | Austrian Science Fund (FWF) - I374-N19 | |
dc.relation | Austrian Science Fund (FWF) - P23711-N19 | |
dc.relation | Agence Nationale de Recherche (France) - ANR-09-BLAN-0420-01 | |
dc.relation | European Commission FP7 program ELISA | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172030/RS// | |
dc.relation | PHC Amadeus | |
dc.relation | OEAD - FR01/2012 | |
dc.rights | openAccess | |
dc.source | Chemistry-A European Journal | |
dc.subject | antitumor agents | en |
dc.subject | lanthanide | en |
dc.subject | nitrosyl | en |
dc.subject | osmium | en |
dc.subject | ruthenium | en |
dc.title | Heteropentanuclear Oxalato-Bridged nd-4f (n=4, 5) Metal Complexes with NO Ligand: Synthesis, Crystal Structures, Aqueous Stability and Antiproliferative Activity | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јовановиц, Катарина К; Ромпел, Aннетте; Лунеау, Доминиqуе; Цремер, Лаура; Aрион, Владимир Б; Кухн, Паул-Стеффен; Радуловиц, Синиса; Филиповиц, Лана; Дојчиновић, Биљана; Хуммер, Aлфред A; Томмасино, Јеан Бернард; Буецхел, Габриел Е; Меиер, Самуел М; Гаврилута, Aнатолие; | |
dc.citation.volume | 21 | |
dc.citation.issue | 39 | |
dc.citation.spage | 13703 | |
dc.citation.epage | 13713 | |
dc.citation.other | 21(39): 13703-13713 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 26260662 | |
dc.identifier.doi | 10.1002/chem.201502026 | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs//bitstream/id/8129/1678.pdf | |
dc.identifier.scopus | 2-s2.0-84941599881 | |
dc.identifier.wos | 000361190200030 | |
dc.type.version | publishedVersion |