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dc.creatorKuhn, Paul-Steffen
dc.creatorCremer, Laura
dc.creatorGavriluta, Anatolie
dc.creatorJovanovic, Katarina K
dc.creatorFilipovic, Lana
dc.creatorHummer, Alfred A
dc.creatorBuechel, Gabriel E
dc.creatorDojčinović, Biljana
dc.creatorMeier, Samuel M
dc.creatorRompel, Annette
dc.creatorRadulovic, Sinisa
dc.creatorTommasino, Jean Bernard
dc.creatorLuneau, Dominique
dc.creatorArion, Vladimir B
dc.date.accessioned2019-01-30T17:44:41Z
dc.date.available2019-01-30T17:44:41Z
dc.date.issued2015
dc.identifier.issn0947-6539
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1680
dc.description.abstractA series of heteropentanuclear oxalate-bridged Ru(NO)-Ln (4d-4f) metal complexes of the general formula (nBu(4)N)(5)[Ln{RuCl3(-ox)(NO)}(4)], where Ln=Y (2), Gd (3), Tb (4), Dy (5) and ox=oxalate anion, were obtained by treatment of (nBu(4)N)(2)[RuCl3(ox)(NO)] (1) with the respective lanthanide salt in 4:1 molar ratio. The compounds were characterized by elemental analysis, IR spectroscopy, electrospray ionization (ESI) mass spectrometry, while 1, 2, and 5 were in addition analyzed by X-ray crystallography, 1 by Ru K-edge XAS and 1 and 2 by (CNMR)-C-13 spectroscopy. X-ray diffraction showed that in 2 and 5 four complex anions [RuCl3(ox)(NO)](2-) are coordinated to Y-III and Dy-III, respectively, with formation of [Ln{RuCl3(-ox)(NO)}(4)](5-) (Ln=Y, Dy). While Y-III is eight-coordinate in 2, Dy-III is nine-coordinate in 5, with an additional coordination of an EtOH molecule. The negative charge is counterbalanced by five nBu(4)N(+) ions present in the crystal structure. The stability of complexes 2 and 5 in aqueous medium was monitored by UV/Vis spectroscopy. The antiproliferative activity of ruthenium-lanthanide complexes 2-5 were assayed in two human cancer cell lines (HeLa and A549) and in a noncancerous cell line (MRC-5) and compared with those obtained for the previously reported Os(NO)-Ln (5d-4f) analogues (nBu(4)N)(5)[Ln{OsCl3(ox)(NO)}(4)] (Ln=Y (6), Gd (7), Tb (8), Dy (9)). Complexes 2-5 were found to be slightly more active than 1 in inhibiting the proliferation of HeLa and A549 cells, and significantly more cytotoxic than 5d-4f metal complexes 6-9 in terms of IC50 values. The highest antiproliferative activity with IC50 values of 20.0 and 22.4M was found for 4 in HeLa and A549 cell lines, respectively. These cytotoxicity results are in accord with the presented ICP-MS data, indicating five- to eightfold greater accumulation of ruthenium versus osmium in human A549 cancer cells.en
dc.publisherWiley-V C H Verlag Gmbh, Weinheim
dc.relationAustrian Science Fund (FWF) - I374-N19
dc.relationAustrian Science Fund (FWF) - P23711-N19
dc.relationAgence Nationale de Recherche (France) - ANR-09-BLAN-0420-01
dc.relationEuropean Commission FP7 program ELISA
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172030/RS//
dc.relationPHC Amadeus
dc.relationOEAD - FR01/2012
dc.rightsopenAccess
dc.sourceChemistry-A European Journal
dc.subjectantitumor agentsen
dc.subjectlanthanideen
dc.subjectnitrosylen
dc.subjectosmiumen
dc.subjectrutheniumen
dc.titleHeteropentanuclear Oxalato-Bridged nd-4f (n=4, 5) Metal Complexes with NO Ligand: Synthesis, Crystal Structures, Aqueous Stability and Antiproliferative Activityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈовановиц, Катарина К; Ромпел, Aннетте; Лунеау, Доминиqуе; Цремер, Лаура; Aрион, Владимир Б; Кухн, Паул-Стеффен; Радуловиц, Синиса; Филиповиц, Лана; Дојчиновић, Биљана; Хуммер, Aлфред A; Томмасино, Јеан Бернард; Буецхел, Габриел Е; Меиер, Самуел М; Гаврилута, Aнатолие;
dc.citation.volume21
dc.citation.issue39
dc.citation.spage13703
dc.citation.epage13713
dc.citation.other21(39): 13703-13713
dc.citation.rankM21
dc.identifier.pmid26260662
dc.identifier.doi10.1002/chem.201502026
dc.identifier.rcubConv_3414
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8129/1678.pdf
dc.identifier.scopus2-s2.0-84941599881
dc.identifier.wos000361190200030
dc.type.versionpublishedVersion


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