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dc.creatorJanicijevic, Jelena
dc.creatorKrajisnik, Danina
dc.creatorCalija, Bojan
dc.creatorDobricic, Vladimir
dc.creatorDakovic, Aleksandra
dc.creatorKrstić, Jugoslav
dc.creatorMarković, Marija
dc.creatorMilic, Jela
dc.date.accessioned2019-01-30T17:42:47Z
dc.date.available2019-01-30T17:42:47Z
dc.date.issued2014
dc.identifier.issn0928-4931
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1589
dc.description.abstractInorganic modification of diatomite was performed with the precipitation product of partially neutralized aluminum sulfate solution at three different mass ratios. The starting and the modified diatomites were characterized by SEM-EDS, FTIR, thermal analysis and zeta potential measurements and evaluated for drug loading capacity in adsorption batch experiments using diclofenac sodium (DS) as a model drug. In vitro drug release studies were performed in phosphate buffer pH 6.8 from comprimates containing: the drug adsorbed onto the selected modified diatomite sample (DAMD), physical mixture of the drug with the selected modified diatomite sample (PMDMD) and physical mixture of the drug with the starting diatomite (PMDD). In vivo acute toxicity testing of the modified diatomite samples was performed on mice. High adsorbent loading of the selected modified diatomite sample (similar to 250 mg/g in 2 h) enabled the preparation of comprimates containing adsorbed DS in the amount near to its therapeutic dose. Drug release studies demonstrated prolonged release of DS over a period of 8 h from both DAMD comprimates (18% after 8 h) and PMDMD comprimates (45% after 8 h). The release kinetics for DAMD and PMDMD comprimates fitted well with Korsmeyer-Peppas and Bhaskar models, indicating that the release mechanism was a combination of non-Fickian diffusion and ion exchange process.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172018/RS//
dc.rightsrestrictedAccess
dc.sourceMaterials Science & Engineering C-Materials For Biological Applications
dc.subjectDiatomiteen
dc.subjectInorganic modificationen
dc.subjectDiclofenac sodiumen
dc.subjectAdsorptionen
dc.subjectProlonged drug releaseen
dc.titleInorganically modified diatomite as a potential prolonged-release drug carrieren
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦалија, Бојан; Крајисник, Данина; Крстић, Југослав; Добрициц, Владимир; Марковиц, Марија; Јаницијевиц, Јелена; Даковиц, Aлександра; Милиц, Јела;
dc.citation.volume42
dc.citation.spage412
dc.citation.epage420
dc.citation.other42: 412-420
dc.citation.rankM22
dc.identifier.pmid25063135
dc.identifier.doi10.1016/j.msec.2014.05.052
dc.identifier.rcubConv_3196
dc.identifier.scopus2-s2.0-84902655546
dc.identifier.wos000340687400052
dc.type.versionpublishedVersion


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