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dc.creatorPantelic, Nebojsa
dc.creatorZmejkovski, Bojana
dc.creatorStanojković, Tatjana
dc.creatorJevtic, Verica V.
dc.creatorRadic, Gordana P.
dc.creatorTrifunovic, Srecko R.
dc.creatorKaluđerović, Goran N.
dc.creatorSabo, Tibor
dc.date.accessioned2019-01-30T17:42:31Z
dc.date.available2019-01-30T17:42:31Z
dc.date.issued2014
dc.identifier.issn0352-5139
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1574
dc.description.abstractA novel (S,S)-R(2)eddip ester, O,O'-diisopentyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, H-1- and C-13-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R(2)eddip esters, dialkyl (S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1-3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC50(Fem-x) value of 1.51 +/- 0.09 mu M.en
dc.publisherSerbian Chemical Soc, Belgrade
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectR(2)edda-type estersen
dc.subjectcharacterizationen
dc.subjectcytotoxicityen
dc.subjectselectivityen
dc.titleSynthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride estersen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractРадиц, Гордана П.; Пантелиц, Небојса; Змејковски, Бојана; Сабо, Тибор Ј.; Трифуновиц, Срецко Р.; Станојковиц, Татјана П.; Калудеровиц, Горан Н.; Јевтиц, Верица В.;
dc.citation.volume79
dc.citation.issue6
dc.citation.spage649
dc.citation.epage658
dc.citation.other79(6): 649-658
dc.citation.rankM23
dc.identifier.doi10.2298/JSC130512022P
dc.identifier.rcubConv_3170
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8040/1572.pdf
dc.identifier.scopus2-s2.0-84903140555
dc.identifier.wos000338268800003
dc.type.versionpublishedVersion


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