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Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters
dc.creator | Pantelić, Nebojša Đ. | |
dc.creator | Zmejkovski, Bojana | |
dc.creator | Stanojković, Tatjana | |
dc.creator | Jevtic, Verica V. | |
dc.creator | Radic, Gordana P. | |
dc.creator | Trifunovic, Srecko R. | |
dc.creator | Kaluđerović, Goran N. | |
dc.creator | Sabo, Tibor | |
dc.date.accessioned | 2019-01-30T17:42:31Z | |
dc.date.available | 2019-01-30T17:42:31Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/1574 | |
dc.description.abstract | A novel (S,S)-R(2)eddip ester, O,O'-diisopentyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, H-1- and C-13-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R(2)eddip esters, dialkyl (S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1-3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC50(Fem-x) value of 1.51 +/- 0.09 mu M. | en |
dc.publisher | Serbian Chemical Soc, Belgrade | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | R(2)edda-type esters | en |
dc.subject | characterization | en |
dc.subject | cytotoxicity | en |
dc.subject | selectivity | en |
dc.title | Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Радиц, Гордана П.; Пантелиц, Небојса; Змејковски, Бојана; Сабо, Тибор Ј.; Трифуновиц, Срецко Р.; Станојковиц, Татјана П.; Калудеровиц, Горан Н.; Јевтиц, Верица В.; | |
dc.citation.volume | 79 | |
dc.citation.issue | 6 | |
dc.citation.spage | 649 | |
dc.citation.epage | 658 | |
dc.citation.other | 79(6): 649-658 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.2298/JSC130512022P | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs//bitstream/id/8040/1572.pdf | |
dc.identifier.scopus | 2-s2.0-84903140555 | |
dc.identifier.wos | 000338268800003 | |
dc.type.version | publishedVersion |