Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines
Samo za registrovane korisnike
2014
Autori
Aljančić, IvanaVučković, Ivan
Jadranin, Milka
Pešić, Milica
Đorđević, Iris
Podolski-Renic, Ana
Stojkovic, Sonja
Menković, Nebojša
Vajs, Vlatka
Milosavljević, Slobodan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.
Ključne reči:
Helichrysum zivojinii / Asteraceae / Chalcone glucoside dimers / Flavonoid glucoside / Topoisomerase II alpha / HIF-1 alpha / MAP kinase pathway / Drug combinationIzvor:
Phytochemistry, 2014, 98, 190-196Izdavač:
- Oxford : Pergamon-Elsevier Science Ltd
Finansiranje / projekti:
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-172053)
- Identifikacija molekularnih markera za predikciju progresije tumora, odgovora na terapiju i ishoda bolesti (RS-41031)
DOI: 10.1016/j.phytochem.2013.11.025
ISSN: 0031-9422
PubMed: 24361288
WoS: 000331020000022
Scopus: 2-s2.0-84892946345
Institucija/grupa
IHTMTY - JOUR AU - Aljančić, Ivana AU - Vučković, Ivan AU - Jadranin, Milka AU - Pešić, Milica AU - Đorđević, Iris AU - Podolski-Renic, Ana AU - Stojkovic, Sonja AU - Menković, Nebojša AU - Vajs, Vlatka AU - Milosavljević, Slobodan PY - 2014 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1542 AB - Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway. PB - Oxford : Pergamon-Elsevier Science Ltd T2 - Phytochemistry T1 - Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines VL - 98 SP - 190 EP - 196 DO - 10.1016/j.phytochem.2013.11.025 ER -
@article{ author = "Aljančić, Ivana and Vučković, Ivan and Jadranin, Milka and Pešić, Milica and Đorđević, Iris and Podolski-Renic, Ana and Stojkovic, Sonja and Menković, Nebojša and Vajs, Vlatka and Milosavljević, Slobodan", year = "2014", abstract = "Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.", publisher = "Oxford : Pergamon-Elsevier Science Ltd", journal = "Phytochemistry", title = "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines", volume = "98", pages = "190-196", doi = "10.1016/j.phytochem.2013.11.025" }
Aljančić, I., Vučković, I., Jadranin, M., Pešić, M., Đorđević, I., Podolski-Renic, A., Stojkovic, S., Menković, N., Vajs, V.,& Milosavljević, S.. (2014). Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry Oxford : Pergamon-Elsevier Science Ltd., 98, 190-196. https://doi.org/10.1016/j.phytochem.2013.11.025
Aljančić I, Vučković I, Jadranin M, Pešić M, Đorđević I, Podolski-Renic A, Stojkovic S, Menković N, Vajs V, Milosavljević S. Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry. 2014;98:190-196. doi:10.1016/j.phytochem.2013.11.025 .
Aljančić, Ivana, Vučković, Ivan, Jadranin, Milka, Pešić, Milica, Đorđević, Iris, Podolski-Renic, Ana, Stojkovic, Sonja, Menković, Nebojša, Vajs, Vlatka, Milosavljević, Slobodan, "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines" in Phytochemistry, 98 (2014):190-196, https://doi.org/10.1016/j.phytochem.2013.11.025 . .