An In Vitro Synergistic Interaction of Combinations of Thymus glabrescens Essential Oil and Its Main Constituents with Chloramphenicol
2014
Аутори
Ilic, Budimir S.Kocic, Branislava D.
Ciric, Vojislav M.
Cvetković, Olga
Miladinovic, Dragoljub L.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The chemical composition and antibacterial activity of Thymus glabrescens Willd. (Lamiaceae) essential oil were examined, as well as the association between it and chloramphenicol. The antibacterial activities of geraniol and thymol, the main constituents of T. glabrescens oil, individually and in combination with chloramphenicol, were also determined. The interactions of the essential oil, geraniol, and thymol with chloramphenicol toward five selected strains were evaluated using the microdilution checkerboard assay in combination with chemometric methods. Oxygenated monoterpenes were the most abundant compound class in the oil, with geraniol (22.33%) as the major compound. The essential oil exhibited in vitro antibacterial activity against all tested bacterial strains, but the activities were lower than those of the standard antibiotic and thymol. A combination of T. glabrescens oil and chloramphenicol produced a strong synergistic interaction (FIC indices in the range 0.21-0.87) and... a substantial reduction of the MIC value of chloramphenicol, thus minimizing its adverse side effects. The combinations geraniol-chloramphenicol and thymol-chloramphenicol produced synergistic interaction to a greater extent, compared with essential oil-chloramphenicol association, which may indicate that the activity of the thyme oil could be attributed to the presence of significant concentrations of geraniol and thymol.
Извор:
Scientific World Journal, 2014Издавач:
- Hindawi Publishing Corporation, New York
Финансирање / пројекти:
- Електрични пробој гасова, површински процеси и примене (RS-MESTD-Basic Research (BR or ON)-171025)
- Геохемијска испитивања седиментних стена - фосилна горива и загађивачи животне средине (RS-MESTD-Basic Research (BR or ON)-176006)
DOI: 10.1155/2014/826219
ISSN: 1537-744X
PubMed: 24616649
WoS: 000330894700001
Scopus: 2-s2.0-84896822340
Институција/група
IHTMTY - JOUR AU - Ilic, Budimir S. AU - Kocic, Branislava D. AU - Ciric, Vojislav M. AU - Cvetković, Olga AU - Miladinovic, Dragoljub L. PY - 2014 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1540 AB - The chemical composition and antibacterial activity of Thymus glabrescens Willd. (Lamiaceae) essential oil were examined, as well as the association between it and chloramphenicol. The antibacterial activities of geraniol and thymol, the main constituents of T. glabrescens oil, individually and in combination with chloramphenicol, were also determined. The interactions of the essential oil, geraniol, and thymol with chloramphenicol toward five selected strains were evaluated using the microdilution checkerboard assay in combination with chemometric methods. Oxygenated monoterpenes were the most abundant compound class in the oil, with geraniol (22.33%) as the major compound. The essential oil exhibited in vitro antibacterial activity against all tested bacterial strains, but the activities were lower than those of the standard antibiotic and thymol. A combination of T. glabrescens oil and chloramphenicol produced a strong synergistic interaction (FIC indices in the range 0.21-0.87) and a substantial reduction of the MIC value of chloramphenicol, thus minimizing its adverse side effects. The combinations geraniol-chloramphenicol and thymol-chloramphenicol produced synergistic interaction to a greater extent, compared with essential oil-chloramphenicol association, which may indicate that the activity of the thyme oil could be attributed to the presence of significant concentrations of geraniol and thymol. PB - Hindawi Publishing Corporation, New York T2 - Scientific World Journal T1 - An In Vitro Synergistic Interaction of Combinations of Thymus glabrescens Essential Oil and Its Main Constituents with Chloramphenicol DO - 10.1155/2014/826219 ER -
@article{ author = "Ilic, Budimir S. and Kocic, Branislava D. and Ciric, Vojislav M. and Cvetković, Olga and Miladinovic, Dragoljub L.", year = "2014", abstract = "The chemical composition and antibacterial activity of Thymus glabrescens Willd. (Lamiaceae) essential oil were examined, as well as the association between it and chloramphenicol. The antibacterial activities of geraniol and thymol, the main constituents of T. glabrescens oil, individually and in combination with chloramphenicol, were also determined. The interactions of the essential oil, geraniol, and thymol with chloramphenicol toward five selected strains were evaluated using the microdilution checkerboard assay in combination with chemometric methods. Oxygenated monoterpenes were the most abundant compound class in the oil, with geraniol (22.33%) as the major compound. The essential oil exhibited in vitro antibacterial activity against all tested bacterial strains, but the activities were lower than those of the standard antibiotic and thymol. A combination of T. glabrescens oil and chloramphenicol produced a strong synergistic interaction (FIC indices in the range 0.21-0.87) and a substantial reduction of the MIC value of chloramphenicol, thus minimizing its adverse side effects. The combinations geraniol-chloramphenicol and thymol-chloramphenicol produced synergistic interaction to a greater extent, compared with essential oil-chloramphenicol association, which may indicate that the activity of the thyme oil could be attributed to the presence of significant concentrations of geraniol and thymol.", publisher = "Hindawi Publishing Corporation, New York", journal = "Scientific World Journal", title = "An In Vitro Synergistic Interaction of Combinations of Thymus glabrescens Essential Oil and Its Main Constituents with Chloramphenicol", doi = "10.1155/2014/826219" }
Ilic, B. S., Kocic, B. D., Ciric, V. M., Cvetković, O.,& Miladinovic, D. L.. (2014). An In Vitro Synergistic Interaction of Combinations of Thymus glabrescens Essential Oil and Its Main Constituents with Chloramphenicol. in Scientific World Journal Hindawi Publishing Corporation, New York.. https://doi.org/10.1155/2014/826219
Ilic BS, Kocic BD, Ciric VM, Cvetković O, Miladinovic DL. An In Vitro Synergistic Interaction of Combinations of Thymus glabrescens Essential Oil and Its Main Constituents with Chloramphenicol. in Scientific World Journal. 2014;. doi:10.1155/2014/826219 .
Ilic, Budimir S., Kocic, Branislava D., Ciric, Vojislav M., Cvetković, Olga, Miladinovic, Dragoljub L., "An In Vitro Synergistic Interaction of Combinations of Thymus glabrescens Essential Oil and Its Main Constituents with Chloramphenicol" in Scientific World Journal (2014), https://doi.org/10.1155/2014/826219 . .