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dc.creatorKolundzija, Branka
dc.creatorMarkovic, Violeta
dc.creatorStanojković, Tatjana
dc.creatorJoksovic, Ljubinka
dc.creatorMatić, Ivana Z.
dc.creatorTodorović, Nina
dc.creatorNikolic, Marijana
dc.creatorJoksovic, Milan D.
dc.date.accessioned2019-01-30T17:41:25Z
dc.date.available2019-01-30T17:41:25Z
dc.date.issued2014
dc.identifier.issn0960-894X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1523
dc.description.abstractA new class of imine derivatives of hybrid chalcone analogues containing anthraquinone scaffold was synthesized and evaluated for their in vitro cytotoxic activity against HeLa, LS174, and A549 cancer cells. The compound 5n with furan ring linked to imino group showed potent activity against all target cells with IC50 values ranging from 1.76 to 6.11 mu M. A mode of action study suggested that compounds induced changes typical for apoptosis in HeLa cells. The most active compounds inhibited tubulogenesis and 5h was found to exhibit a strong anti-angiogenic effect.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.rightsrestrictedAccess
dc.sourceBioorganic and Medicinal Chemistry Letters
dc.subjectChalconeen
dc.subjectAnthraquinoneen
dc.subjectcytotoxicityen
dc.subjectAngiogenesisen
dc.titleNovel anthraquinone based chalcone analogues containing an imine fragment: Synthesis, cytotoxicity and anti-angiogenic activityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТодоровић, Нина; Јоксовиц, Милан Д.; Марковиц, Виолета; Николиц, Маријана; Колундзија, Бранка; Станојковиц, Татјана; Јоксовиц, Љубинка; Матиц, Ивана;
dc.citation.volume24
dc.citation.issue1
dc.citation.spage65
dc.citation.epage71
dc.citation.other24(1): 65-71
dc.citation.rankM22
dc.identifier.pmid24332490
dc.identifier.doi10.1016/j.bmcl.2013.11.075
dc.identifier.rcubConv_3084
dc.identifier.scopus2-s2.0-84891488134
dc.identifier.wos000329114200008
dc.type.versionpublishedVersion


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