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Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole
dc.creator | Vasić, Vesna P. | |
dc.creator | Penjišević, Jelena | |
dc.creator | Novaković, Irena | |
dc.creator | Šukalović, Vladimir | |
dc.creator | Andrić, Deana | |
dc.creator | Kostić Rajačić, Slađana | |
dc.date.accessioned | 2019-01-30T17:41:06Z | |
dc.date.available | 2019-01-30T17:41:06Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/1511 | |
dc.description.abstract | A series of eight novel 5-substituted derivatives of benzimidazole was synthesized by condensation of the corresponding diamine with ethyl 4-[4-(2-chlorophenyl)piperazin-1-yl]butanoate in refluxing 4 M hydrochloric acid. In vitro antibacterial activity against ten strains, namely Bacillus subtilis, Clostridium sporogenes, Streptosporangium longisporum, Micrococcus flavus, Sarcina lutea, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris and antifungal activity against two fungal strains, namely Candida albicans and Saccharomyces cerevisiae, were evaluated. Of all the compounds screened for activity, 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-iodo-1H-benzimidazole and 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-methyl-1H-benzimidazole were associated with higher antifungal activity than commercial drugs. | en |
dc.publisher | Serbian Chemical Soc, Belgrade | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172032/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | arylpiperazines | en |
dc.subject | benzimidazoles | en |
dc.subject | antibacterial activity | en |
dc.subject | antifungal activity | en |
dc.title | Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Васиц, Весна П.; Шукаловић, Владимир; Новаковић, Ирена; Пењишевић, Јелена; Aндриц, Деана Б.; Костић Рајачић, Слађана; | |
dc.citation.volume | 79 | |
dc.citation.issue | 3 | |
dc.citation.spage | 277 | |
dc.citation.epage | 282 | |
dc.citation.other | 79(3): 277-282 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.2298/JSC130418058V | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs//bitstream/id/7981/1509.pdf | |
dc.identifier.scopus | 2-s2.0-84896935228 | |
dc.identifier.wos | 000333770600001 | |
dc.type.version | publishedVersion |