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dc.creatorVasic, Vesna P.
dc.creatorPenjišević, Jelena
dc.creatorNovaković, Irena
dc.creatorŠukalović, Vladimir
dc.creatorAndrić, Deana
dc.creatorKostić Rajačić, Slađana
dc.date.accessioned2019-01-30T17:41:06Z
dc.date.available2019-01-30T17:41:06Z
dc.date.issued2014
dc.identifier.issn0352-5139
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1511
dc.description.abstractA series of eight novel 5-substituted derivatives of benzimidazole was synthesized by condensation of the corresponding diamine with ethyl 4-[4-(2-chlorophenyl)piperazin-1-yl]butanoate in refluxing 4 M hydrochloric acid. In vitro antibacterial activity against ten strains, namely Bacillus subtilis, Clostridium sporogenes, Streptosporangium longisporum, Micrococcus flavus, Sarcina lutea, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris and antifungal activity against two fungal strains, namely Candida albicans and Saccharomyces cerevisiae, were evaluated. Of all the compounds screened for activity, 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-iodo-1H-benzimidazole and 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-methyl-1H-benzimidazole were associated with higher antifungal activity than commercial drugs.en
dc.publisherSerbian Chemical Soc, Belgrade
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172032/RS//
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectarylpiperazinesen
dc.subjectbenzimidazolesen
dc.subjectantibacterial activityen
dc.subjectantifungal activityen
dc.titleSynthesis and biological evaluation of 5-substituted derivatives of benzimidazoleen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractВасиц, Весна П.; Шукаловић, Владимир; Новаковић, Ирена; Пењишевић, Јелена; Aндриц, Деана Б.; Костић Рајачић, Слађана;
dc.citation.volume79
dc.citation.issue3
dc.citation.spage277
dc.citation.epage282
dc.citation.other79(3): 277-282
dc.citation.rankM23
dc.identifier.doi10.2298/JSC130418058V
dc.identifier.rcubConv_3135
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/7981/1509.pdf
dc.identifier.scopus2-s2.0-84896935228
dc.identifier.wos000333770600001
dc.type.versionpublishedVersion


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