Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity
Samo za registrovane korisnike
2014
Autori
Filipovic, NenadGrubišić, Sonja
Jovanović, Maja
Dulovic, Marija
Markovic, Ivanka
Klisurić, Olivera
Marinković, Aleksandar D.
Mitić, Dragana
Anđelković, Katarina
Todorović, Tamara
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Novel Pd(II) complex with N-heteroaromatic Schiff base ligand, derived from 8-quinolinecarboxaldehyde (q8a) and ethyl hydrazinoacetate (haOEt), was synthesized and characterized by analytical and spectroscopy methods. The structure of novel complex, as well as structures of its quinoline and pyridine analogues, was optimized by density functional theory calculations, and theoretical data show good agreement with experimental results. A cytotoxic action of the complexes was evaluated on cultures of human promyelocytic leukemia (HL-60), human glioma (U251), rat glioma (C6), and mouse fibrosarcoma (L929) cell lines. Among investigated compounds, only complexes with quinoline-based ligands reduce the cell numbers in a dose-dependent manner in investigated cell lines. The observed cytotoxic effect of two isomeric quinoline-based complexes is predominantly mediated through the induction of apoptotic cell death in HL-60 cell line. The cytotoxicity of most efficient novel Pd(II) complex is com...parable to the activity of cisplatin, in all cell lines investigated.
Ključne reči:
apoptosis / biological screening / chemical structure / palladium(II) complexes / X-ray crystallographyIzvor:
Chemical Biology & Drug Design, 2014, 84, 3, 333-341Izdavač:
- Wiley-Blackwell, Hoboken
Finansiranje / projekti:
- Interakcije prirodnih proizvoda, njihovih derivata i kompleksnih jedinjenja sa proteinima i nukleinskim kiselinama (RS-MESTD-Basic Research (BR or ON)-172055)
- Modulacija signalnih puteva koji kontrolišu intracelularni energetski balans u terapiji tumora i neuro-imuno-endokrinih poremećaja (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41025)
DOI: 10.1111/cbdd.12322
ISSN: 1747-0277
PubMed: 24636459
WoS: 000342978100009
Scopus: 2-s2.0-84905821443
Institucija/grupa
IHTMTY - JOUR AU - Filipovic, Nenad AU - Grubišić, Sonja AU - Jovanović, Maja AU - Dulovic, Marija AU - Markovic, Ivanka AU - Klisurić, Olivera AU - Marinković, Aleksandar D. AU - Mitić, Dragana AU - Anđelković, Katarina AU - Todorović, Tamara PY - 2014 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1498 AB - Novel Pd(II) complex with N-heteroaromatic Schiff base ligand, derived from 8-quinolinecarboxaldehyde (q8a) and ethyl hydrazinoacetate (haOEt), was synthesized and characterized by analytical and spectroscopy methods. The structure of novel complex, as well as structures of its quinoline and pyridine analogues, was optimized by density functional theory calculations, and theoretical data show good agreement with experimental results. A cytotoxic action of the complexes was evaluated on cultures of human promyelocytic leukemia (HL-60), human glioma (U251), rat glioma (C6), and mouse fibrosarcoma (L929) cell lines. Among investigated compounds, only complexes with quinoline-based ligands reduce the cell numbers in a dose-dependent manner in investigated cell lines. The observed cytotoxic effect of two isomeric quinoline-based complexes is predominantly mediated through the induction of apoptotic cell death in HL-60 cell line. The cytotoxicity of most efficient novel Pd(II) complex is comparable to the activity of cisplatin, in all cell lines investigated. PB - Wiley-Blackwell, Hoboken T2 - Chemical Biology & Drug Design T1 - Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity VL - 84 IS - 3 SP - 333 EP - 341 DO - 10.1111/cbdd.12322 ER -
@article{ author = "Filipovic, Nenad and Grubišić, Sonja and Jovanović, Maja and Dulovic, Marija and Markovic, Ivanka and Klisurić, Olivera and Marinković, Aleksandar D. and Mitić, Dragana and Anđelković, Katarina and Todorović, Tamara", year = "2014", abstract = "Novel Pd(II) complex with N-heteroaromatic Schiff base ligand, derived from 8-quinolinecarboxaldehyde (q8a) and ethyl hydrazinoacetate (haOEt), was synthesized and characterized by analytical and spectroscopy methods. The structure of novel complex, as well as structures of its quinoline and pyridine analogues, was optimized by density functional theory calculations, and theoretical data show good agreement with experimental results. A cytotoxic action of the complexes was evaluated on cultures of human promyelocytic leukemia (HL-60), human glioma (U251), rat glioma (C6), and mouse fibrosarcoma (L929) cell lines. Among investigated compounds, only complexes with quinoline-based ligands reduce the cell numbers in a dose-dependent manner in investigated cell lines. The observed cytotoxic effect of two isomeric quinoline-based complexes is predominantly mediated through the induction of apoptotic cell death in HL-60 cell line. The cytotoxicity of most efficient novel Pd(II) complex is comparable to the activity of cisplatin, in all cell lines investigated.", publisher = "Wiley-Blackwell, Hoboken", journal = "Chemical Biology & Drug Design", title = "Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity", volume = "84", number = "3", pages = "333-341", doi = "10.1111/cbdd.12322" }
Filipovic, N., Grubišić, S., Jovanović, M., Dulovic, M., Markovic, I., Klisurić, O., Marinković, A. D., Mitić, D., Anđelković, K.,& Todorović, T.. (2014). Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity. in Chemical Biology & Drug Design Wiley-Blackwell, Hoboken., 84(3), 333-341. https://doi.org/10.1111/cbdd.12322
Filipovic N, Grubišić S, Jovanović M, Dulovic M, Markovic I, Klisurić O, Marinković AD, Mitić D, Anđelković K, Todorović T. Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity. in Chemical Biology & Drug Design. 2014;84(3):333-341. doi:10.1111/cbdd.12322 .
Filipovic, Nenad, Grubišić, Sonja, Jovanović, Maja, Dulovic, Marija, Markovic, Ivanka, Klisurić, Olivera, Marinković, Aleksandar D., Mitić, Dragana, Anđelković, Katarina, Todorović, Tamara, "Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity" in Chemical Biology & Drug Design, 84, no. 3 (2014):333-341, https://doi.org/10.1111/cbdd.12322 . .