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dc.creatorŠukalović, Vladimir
dc.creatorŠoškić, Vukić
dc.creatorIgnjatović, Đurđica S.
dc.creatorAndrić, Deana
dc.creatorPenjišević, Jelena
dc.creatorKostić Rajačić, Slađana
dc.date.accessioned2019-01-30T17:40:39Z
dc.date.available2019-01-30T17:40:39Z
dc.date.issued2014
dc.identifier.issn0352-5139
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1488
dc.description.abstractThe dopaminergic receptor system has been the focus for the development of new pharmacotherapeutic agents targeting a number of central nervous system related disorders, such as drug addiction, schizophrenia, depression, and Parkinson's disease, to name just a few. To date, the crystal structure for the human D2 receptor is not known, despite its vital function and importance as a therapeutic target. Herein, a recent advancement in the determination of key receptor ligand interactions for the available arylpiperazine-like ligands, using a D2 receptor model based on the crystal structure of the D3 receptor is presented. To determine key interactions responsible for high dopaminergic activity, computer-docking analysis was used together with experimental data. A total of 4 dopaminergic ligands showing moderate to high affinity were tested and the obtained results rationalized using ligand structures docked into the proposed D2 receptor model.en
dc.publisherSerbian Chemical Soc, Belgrade
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172032/RS//
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectarylpiperazineen
dc.subjectG protein-coupled receptorsen
dc.subjectdockingen
dc.subjectmolecular modelingen
dc.titleInvestigation of key interactions between the second extracellular loop of the dopamine D2 receptor and several hydroxy-N-{[2-(4-phenylpiperazin-1-yl)ethyl]phenyl}nicotinamidesen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractИгњатовић, Ђурђица С.; Костић Рајачић, Слађана; Соскиц, Вукиц; Aндриц, Деана; Пењишевић, Јелена; Шукаловић, Владимир;
dc.citation.volume79
dc.citation.issue12
dc.citation.spage1461
dc.citation.epage1467
dc.citation.other79(12): 1461-1467
dc.citation.rankM23
dc.identifier.doi10.2298/JSC140423070S
dc.identifier.rcubConv_3278
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/7959/1486.pdf
dc.identifier.scopus2-s2.0-84920829324
dc.identifier.wos000348749400001
dc.type.versionpublishedVersion


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