Prikaz osnovnih podataka o dokumentu
Surface characterization, hemo- and cytocompatibility of segmented poly(dimethylsiloxane)-based polyurethanes
Površinska karakterizacija, hemo- i citokompatibilnost segmentiranih poliuretana na bazi poli(dimetilsiloksana)
dc.creator | Pergal, Marija | |
dc.creator | Nestorov, Jelena | |
dc.creator | Tovilović-Kovačević, Gordana | |
dc.creator | Jovančić, Petar | |
dc.creator | Pezo, Lato | |
dc.creator | Vasiljević-Radović, Dana | |
dc.creator | Đonlagić, Jasna | |
dc.date.accessioned | 2019-01-30T17:40:00Z | |
dc.date.available | 2019-01-30T17:40:00Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0367-598X | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/1456 | |
dc.description.abstract | Segmented polyurethanes based on poly(dimethylsiloxane), currently used for biomedical applications, have sub-optimal biocompatibility which reduces their efficacy. Improving the endothelial cell attachment and blood-contacting properties of PDMS-based copolymers would substantially improve their clinical applications. We have studied the surface properties and in vitro biocompatibility of two series of segmented poly(urethane-dimethylsiloxane)s (SPU-PDMS) based on hydroxypropyl- and hydroxyethoxypropyl-terminated PDMS with potential applications in blood-contacting medical devices. SPU-PDMS copolymers were characterized by contact angle measurements, surface free energy determination (calculated using the van Oss-Chaudhury-Good and Owens-Wendt methods), and atomic force microscopy. The biocompatibility of copolymers was evaluated using an endothelial EA.hy926 cell line by direct contact assay, before and after pre-treatment of copolymers with multicomponent protein mixture, as well as by a competitive blood-protein adsorption assay. The obtained results suggested good blood compatibility of synthesized copolymers. All copolymers exhibited good resistance to fibrinogen adsorption and all favored albumin adsorption. Copolymers based on hydroxyethoxypropyl-PDMS had lower hydrophobicity, higher surface free energy and better microphase separation in comparison with hydroxypropyl-PDMS-based copolymers, which promoted better endothelial cell attachment and growth on the surface of these polymers as compared to hydroxypropyl-PDMS-based copolymers. The results showed that SPU-PDMS copolymers display good surface properties, depending on the type of soft PDMS segments, which can be tailored for biomedical application requirements such as biomedical devices for short- and long-term uses. | en |
dc.description.abstract | Segmentirani poliuretani na bazi poli(dimetilsiloksana), koji se trenutno koriste u biomedicini, imaju biokompatibilnost ispod optimalne što smanjuje njihovu efikasnost. Poboljšavajući vezivanje endotelnih ćelija i svojstva kopolimera na bazi PDMS u dodiru sa krvlju značajno bi se poboljšala i proširila njihova klinička primena. U ovom radu su proučavana površinska svojstva i in vitro biokompatibilnost dve serije segmentiranih poli(uretan-dimetilsiloksana) (SPU-PDMS) na bazi hidroksipropil- i hidroksietoksipropil- PDMS pretpolimera sa potencijalnim primenama u medicinskim uredjajima u kontaktu sa krvlju. SPU-PDMS kopolimeri su karakterisani merenjem kontaktnih uglova, određivanjem površinske energije (izračunate prema van Oss-Chaudhury-Good i Owens-Wendt metodama), i mikroskopijom atomskih sila. Biokompatibilnost kopolimera je ispitivana primenom endotelnih EA.hy926 ćelija u direktnom kontaktu, pre i nakon pretretiranja kopolimera sa višekomponentnom smešom proteina, kao i pomoću kompetitivne adsorpcije proteina. Dobijeni rezultati su potvrdili da sintetisani kopolimeri imaju dobru kompatibilnost prema krvi. Svi sintetisani kopolimeri pokazivali su dobru otpornost prema adsorpciji fibrinogena i svi kopolimeri su favorizovali adsorpciju albumina. Kopolimeri na bazi hidroksietoksipropil-PDMS imali su manju hidrofobnost, veću površinsku energiju, i bolju mikrofaznu separaciju u poređenju sa kopolimerima na bazi hidroksipropil-PDMS, što je dovelo do boljeg vezivanja i rasta endotelnih ćelija na površini ovih polimera u poređenju sa kopolimerima na bazi hidroksipropil-PDMS. Rezultati su pokazali da SPU-PDMS kopolimeri prikazuju dobra površinska svojstva, zavisno od vrste mekih PDMS segmenata, koja se mogu prilagođavati zahtevima u biomedicini, kao što su biomedicinski uređaji za kratkoročnu i dugoročnu upotrebu. | sr |
dc.publisher | Association of Chemical Engineers of Serbia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Hemijska industrija | |
dc.subject | polyurethanes | en |
dc.subject | siloxanes | en |
dc.subject | surface free energy | en |
dc.subject | cell adhesion | en |
dc.subject | protein adsorption | en |
dc.subject | Poliuretani | sr |
dc.subject | Siloksani | sr |
dc.subject | Površinska energija | sr |
dc.subject | Vezivanje ćelija | sr |
dc.subject | Adsorpcija proteina | sr |
dc.title | Surface characterization, hemo- and cytocompatibility of segmented poly(dimethylsiloxane)-based polyurethanes | en |
dc.title | Površinska karakterizacija, hemo- i citokompatibilnost segmentiranih poliuretana na bazi poli(dimetilsiloksana) | sr |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Пезо, Лато; Ђонлагић, Јасна; Јованчић, Петар; Несторов, Јелена; Пергал, Марија; Товиловић-Ковачевић, Гордана; Васиљевић-Радовић, Дана; Површинска карактеризација, хемо- и цитокомпатибилност сегментираних полиуретана на бази поли(диметилсилоксана); Површинска карактеризација, хемо- и цитокомпатибилност сегментираних полиуретана на бази поли(диметилсилоксана); | |
dc.citation.volume | 68 | |
dc.citation.issue | 6 | |
dc.citation.spage | 731 | |
dc.citation.epage | 741 | |
dc.citation.other | 68(6): 731-741 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.2298/HEMIND141103082P | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs//bitstream/id/7928/1454.pdf | |
dc.identifier.scopus | 2-s2.0-84920481537 | |
dc.identifier.wos | 000348405900008 | |
dc.type.version | publishedVersion |