Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate
Samo za registrovane korisnike
2013
Autori
Milenković, Milica R.Bacchi, Alessia
Cantoni, Giulia
Radulovic, Sinisa
Gligorijević, Nevenka
Arandelovic, Sandra
Sladić, Dušan
Vujčić, Miroslava
Mitić, Dragana
Anđelković, Katarina
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A cobalt(III) complex with the condensation derivative of 2-(diphenylphosphino) benzaldehyde and ethyl carbazate was synthesized. X-ray crystal structure was determined for both the ligand and the complex. In the cobalt(III) complex two deprotonated ligand molecules coordinate the metal atom in a distorted octahedral geometry by chelation through the PNO donor system formed by the phosphorus, the imine nitrogen and the carbonyl oxygen. The complex showed a moderate antibacterial activity and a strong cytotoxic activity, stronger than cisplatin. Based on cell cycle progression, apoptotic assays, spectroscopic and electrophoretic studies, it was shown that high cytotoxicity and moderate potential of induction of apoptosis are not consequence of interactions with DNA.
Ključne reči:
Cobalt(III) complex / X-ray / Antitumor activity / Antimicrobial activity / DNA bindingIzvor:
Inorganica Chimica Acta, 2013, 395, 33-43Izdavač:
- Elsevier Science Sa, Lausanne
Finansiranje / projekti:
- Interakcije prirodnih proizvoda, njihovih derivata i kompleksnih jedinjenja sa proteinima i nukleinskim kiselinama (RS-172055)
- Farmakodinamska i farmakogenomska ispitivanja novijih lekova u lečenju solidnih tumora (RS-41026)
DOI: 10.1016/j.ica.2012.09.043
ISSN: 0020-1693
WoS: 000316740200005
Scopus: 2-s2.0-84870889620
Institucija/grupa
IHTMTY - JOUR AU - Milenković, Milica R. AU - Bacchi, Alessia AU - Cantoni, Giulia AU - Radulovic, Sinisa AU - Gligorijević, Nevenka AU - Arandelovic, Sandra AU - Sladić, Dušan AU - Vujčić, Miroslava AU - Mitić, Dragana AU - Anđelković, Katarina PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1356 AB - A cobalt(III) complex with the condensation derivative of 2-(diphenylphosphino) benzaldehyde and ethyl carbazate was synthesized. X-ray crystal structure was determined for both the ligand and the complex. In the cobalt(III) complex two deprotonated ligand molecules coordinate the metal atom in a distorted octahedral geometry by chelation through the PNO donor system formed by the phosphorus, the imine nitrogen and the carbonyl oxygen. The complex showed a moderate antibacterial activity and a strong cytotoxic activity, stronger than cisplatin. Based on cell cycle progression, apoptotic assays, spectroscopic and electrophoretic studies, it was shown that high cytotoxicity and moderate potential of induction of apoptosis are not consequence of interactions with DNA. PB - Elsevier Science Sa, Lausanne T2 - Inorganica Chimica Acta T1 - Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate VL - 395 SP - 33 EP - 43 DO - 10.1016/j.ica.2012.09.043 ER -
@article{ author = "Milenković, Milica R. and Bacchi, Alessia and Cantoni, Giulia and Radulovic, Sinisa and Gligorijević, Nevenka and Arandelovic, Sandra and Sladić, Dušan and Vujčić, Miroslava and Mitić, Dragana and Anđelković, Katarina", year = "2013", abstract = "A cobalt(III) complex with the condensation derivative of 2-(diphenylphosphino) benzaldehyde and ethyl carbazate was synthesized. X-ray crystal structure was determined for both the ligand and the complex. In the cobalt(III) complex two deprotonated ligand molecules coordinate the metal atom in a distorted octahedral geometry by chelation through the PNO donor system formed by the phosphorus, the imine nitrogen and the carbonyl oxygen. The complex showed a moderate antibacterial activity and a strong cytotoxic activity, stronger than cisplatin. Based on cell cycle progression, apoptotic assays, spectroscopic and electrophoretic studies, it was shown that high cytotoxicity and moderate potential of induction of apoptosis are not consequence of interactions with DNA.", publisher = "Elsevier Science Sa, Lausanne", journal = "Inorganica Chimica Acta", title = "Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate", volume = "395", pages = "33-43", doi = "10.1016/j.ica.2012.09.043" }
Milenković, M. R., Bacchi, A., Cantoni, G., Radulovic, S., Gligorijević, N., Arandelovic, S., Sladić, D., Vujčić, M., Mitić, D.,& Anđelković, K.. (2013). Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate. in Inorganica Chimica Acta Elsevier Science Sa, Lausanne., 395, 33-43. https://doi.org/10.1016/j.ica.2012.09.043
Milenković MR, Bacchi A, Cantoni G, Radulovic S, Gligorijević N, Arandelovic S, Sladić D, Vujčić M, Mitić D, Anđelković K. Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate. in Inorganica Chimica Acta. 2013;395:33-43. doi:10.1016/j.ica.2012.09.043 .
Milenković, Milica R., Bacchi, Alessia, Cantoni, Giulia, Radulovic, Sinisa, Gligorijević, Nevenka, Arandelovic, Sandra, Sladić, Dušan, Vujčić, Miroslava, Mitić, Dragana, Anđelković, Katarina, "Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate" in Inorganica Chimica Acta, 395 (2013):33-43, https://doi.org/10.1016/j.ica.2012.09.043 . .