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Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis
dc.creator | Matić, Ivana Z. | |
dc.creator | Aljančić, Ivana | |
dc.creator | Vajs, Vlatka | |
dc.creator | Jadranin, Milka | |
dc.creator | Gligorijević, Nevenka | |
dc.creator | Milosavljević, Slobodan | |
dc.creator | Juranić, Zorica | |
dc.date.accessioned | 2019-01-30T17:35:59Z | |
dc.date.available | 2019-01-30T17:35:59Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1934-578X | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/1264 | |
dc.description.abstract | Helichrysum zivojinii Cernjavski & Soska is an endemic plant species that grows in the National Park Galicica in Macedonia. Five extracts were isolated as fractions from the aerial parts of the plant: a n-hexane extract (1), a dichloromethane extract (2), an ethyl-acetate extract (3), a n-butanol extract (4) and a methanol extract (5). A dose-dependent cytotoxic activity of the extracts on MDA-MB-231 and EA.hy926 cells was observed. Extracts exhibited more pronounced cytotoxic actions on MDA-MB-231 cells than on EA.hy926 cells. The n-hexane extract (1), at a non-toxic concentration, exhibited an inhibitory effect on the migration as well the invasiveness of MDA-MB-231 cells. The dichloromethane extract (2), at a non-toxic concentration, demonstrated inhibition of MDA-MB-231 cells invasion. Each of the five extracts applied at non-toxic concentrations inhibited migration of EA.hy926 cells. The prominent inhibitory effect of the n-hexane extract on EA.hy926 cells migration was associated with a notable anti-angiogenic action of this extract. The other four tested extracts demonstrated mild anti-angiogenic activity. Our data highlight the prominent anticancer potential of n-hexane (1) and dichloromethane (2) extracts, which could be attributed to their very pronounced and selective cytotoxic activities as well as their anti-invasive and anti-angiogenic properties. | en |
dc.publisher | Natural Products Inc, Westerville | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.rights | openAccess | |
dc.source | Natural Product Communications | |
dc.subject | Helichrysum zivojinii | en |
dc.subject | MDA-MB-231 | en |
dc.subject | EA.hy926 | en |
dc.subject | cytotoxic action | en |
dc.subject | Invasiveness | en |
dc.subject | Angiogenesis in vitro | en |
dc.title | Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јадранин, Милка; Милосављевиц, Слободан; Глигоријевиц, Невенка; Aљанчић, Ивана С.; Јураниц, Зорица Д.; Вајс, Влатка; Матиц, Ивана З.; | |
dc.citation.volume | 8 | |
dc.citation.issue | 9 | |
dc.citation.spage | 1291 | |
dc.citation.epage | 1296 | |
dc.citation.other | 8(9): 1291-1296 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 24273869 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_cherry_1435 | |
dc.identifier.scopus | 2-s2.0-84886856412 | |
dc.identifier.wos | 000326858000027 | |
dc.type.version | publishedVersion |