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dc.creatorMatić, Ivana Z.
dc.creatorAljančić, Ivana
dc.creatorVajs, Vlatka
dc.creatorJadranin, Milka
dc.creatorGligorijevic, Nevenka
dc.creatorMilosavljević, Slobodan
dc.creatorJuranić, Zorica
dc.date.accessioned2019-01-30T17:35:59Z
dc.date.available2019-01-30T17:35:59Z
dc.date.issued2013
dc.identifier.issn1934-578X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1264
dc.description.abstractHelichrysum zivojinii Cernjavski & Soska is an endemic plant species that grows in the National Park Galicica in Macedonia. Five extracts were isolated as fractions from the aerial parts of the plant: a n-hexane extract (1), a dichloromethane extract (2), an ethyl-acetate extract (3), a n-butanol extract (4) and a methanol extract (5). A dose-dependent cytotoxic activity of the extracts on MDA-MB-231 and EA.hy926 cells was observed. Extracts exhibited more pronounced cytotoxic actions on MDA-MB-231 cells than on EA.hy926 cells. The n-hexane extract (1), at a non-toxic concentration, exhibited an inhibitory effect on the migration as well the invasiveness of MDA-MB-231 cells. The dichloromethane extract (2), at a non-toxic concentration, demonstrated inhibition of MDA-MB-231 cells invasion. Each of the five extracts applied at non-toxic concentrations inhibited migration of EA.hy926 cells. The prominent inhibitory effect of the n-hexane extract on EA.hy926 cells migration was associated with a notable anti-angiogenic action of this extract. The other four tested extracts demonstrated mild anti-angiogenic activity. Our data highlight the prominent anticancer potential of n-hexane (1) and dichloromethane (2) extracts, which could be attributed to their very pronounced and selective cytotoxic activities as well as their anti-invasive and anti-angiogenic properties.en
dc.publisherNatural Products Inc, Westerville
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.rightsopenAccess
dc.sourceNatural Product Communications
dc.subjectHelichrysum zivojiniien
dc.subjectMDA-MB-231en
dc.subjectEA.hy926en
dc.subjectcytotoxic actionen
dc.subjectInvasivenessen
dc.subjectAngiogenesis in vitroen
dc.titleCancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈадранин, Милка; Милосављевиц, Слободан; Глигоријевиц, Невенка; Aљанчић, Ивана С.; Јураниц, Зорица Д.; Вајс, Влатка; Матиц, Ивана З.;
dc.citation.volume8
dc.citation.issue9
dc.citation.spage1291
dc.citation.epage1296
dc.citation.other8(9): 1291-1296
dc.citation.rankM23
dc.identifier.pmid24273869
dc.identifier.rcubConv_3068
dc.identifier.scopus2-s2.0-84886856412
dc.identifier.wos000326858000027
dc.type.versionpublishedVersion


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