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dc.creatorBalijagic, Jasmina
dc.creatorJankovic, Teodora
dc.creatorZdunic, Gordana
dc.creatorBoskovic, Jelena
dc.creatorSavikin, Katarina
dc.creatorGođevac, Dejan
dc.creatorStanojković, Tatjana
dc.creatorJovancevic, Miodrag
dc.creatorMenković, Nebojša
dc.date.accessioned2019-01-30T17:32:58Z
dc.date.available2019-01-30T17:32:58Z
dc.date.issued2012
dc.identifier.issn1934-578X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1122
dc.description.abstractLC-ESI-MS and HPLC were used for the identification of the constituents from G. lutea leaves collected at different localities, as well as for quantification of the main compounds. Seven secoiridoids, five C-glucoflavones and three xanthones, were identified. Swertiamarin derivatives, namely eustornorusside (2), eustomoside (3) and septemfidoside (5), were detected in G. lutea for the first time. Concentrations of five constituents (swertiamarin, gentiopicrin, isovitexin, mangiferin and isogentisin) were determined. The relationship between concentrations of gamma-pyrones and altitude was observed with statistically significant correlation (r = 0.94). The extracts were also evaluated for their content of total phenolics, and antiradical and cytotoxic activities. The total phenolics content ranged from 7.7 to 12.7 mg GAE/g, and the IC50 values for DPPH radical scavenging activity varied between 0.45 to 2.02 mg/mL. The leaf extract exhibited moderate cytotoxic effects toward HeLa cells with an IC50 value of 41.1 mu g/mL, while gentiopicrin, mangiferin and isogentisin exerted strong activity against HeLa cells, with IC50 values ranging from 5.7 to 8.8 mu g/mL. The results confirm the traditional usage of G. lutea leaves and also suggest their possible utilization as hepatoprotective, hypoglycemic and anti-inflammatory agents.en
dc.publisherNatural Products Inc, Westerville
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46013/RS//
dc.rightsopenAccess
dc.sourceNatural Product Communications
dc.subjectGentiana lutea leavesen
dc.subjectSecoiridoidsen
dc.subjectFlavonoidsen
dc.subjectcytotoxicityen
dc.titleChemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegroen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈанковиц, Теодора; Станојковиц, Татјана; Савикин, Катарина; Здуниц, Гордана; Гођевац, Дејан; Јованцевиц, Миодраг; Босковиц, Јелена; Балијагиц, Јасмина; Менковиц, Небојса;
dc.citation.volume7
dc.citation.issue11
dc.citation.spage1487
dc.citation.epage1490
dc.citation.other7(11): 1487-1490
dc.citation.rankM22
dc.identifier.pmid23285813
dc.identifier.rcubConv_2878
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/14923/1934578x1200701119.pdf
dc.identifier.scopus2-s2.0-84869814610
dc.identifier.wos000311663700019
dc.type.versionpublishedVersion


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