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dc.creatorPergal, Marija
dc.creatorAntic, Vesna V.
dc.creatorTovilovic, Gordana
dc.creatorNestorov, Jelena
dc.creatorVasiljević-Radović, Dana
dc.creatorDjonlagic, Jasna
dc.date.accessioned2019-01-30T17:32:42Z
dc.date.available2019-01-30T17:32:42Z
dc.date.issued2012
dc.identifier.issn0920-5063
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1110
dc.description.abstractNovel polyurethane co-polymers (TPUs), based on poly(epsilon-caprolactone)-block-poly(dimethylsiloxane)-block-poly(epsilon-caprolactone) (PCL-PDMS-PCL) as soft segment and 4,4'-methylenediphenyl diisocyanate (MDI) and 1,4-butanediol (BD) as hard segment, were synthesized and evaluated for biomedical applications. The content of hard segments (HS) in the polymer chains was varied from 9 to 63 wt%. The influence of the content and length of the HS on the thermal, surface, mechanical properties and biocompatibility was investigated. The structure, composition and HS length were examined using H-1- and quantitative C-13-NMR spectroscopy. DSC results implied that the synthesized TPUs were semicrystalline polymers in which both the hard MDI/BD and soft PCL-PDMS-PCL segments participated. It was found that an increase in the average HS length (from 1.2 to 14.4 MDI/BD units) was accompanied by an increase in the crystallinity of the hard segments, storage moduli, hydrophilicity and degree of microphase separation of the co-polymers. Depending on the HS content, a gradual variation in surface properties of co-polymers was revealed by FTIR, AFM and static water contact angle measurements. The in vitro biocompatibility of co-polymers was evaluated using the endothelial EA. hy926 cell line and protein adsorption on the polyurethane films. All synthesized TPUs adsorbed more albumin than fibrinogen from multicomponent protein mixture, which may indicate biocompatibility. The polyurethane films with high HS content and/or high roughness coefficient exhibit good surface properties and biocompatible behavior, which was confirmed by non-toxic effects to cells and good cell adhesion. Therefore, the non-cytotoxic chemistry of the co-polymers makes them good candidates for further development as biomedical implants.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Biomaterials Science-Polymer Edition
dc.subjectSegmented polyurethanesen
dc.subjectbiocompatibilityen
dc.subjectsurface propertiesen
dc.subjectalpha,omega-dihydroxy-(PCL-PDMS-PCL)en
dc.subjectendothelial cellsen
dc.titleIn Vitro Biocompatibility Evaluation of Novel Urethane-Siloxane Co-Polymers Based on Poly(epsilon-Caprolactone)-block-Poly(Dimethylsiloxane)-block-Poly(epsilon-Caprolactone)en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДјонлагиц, Јасна; Товиловиц, Гордана; Васиљевић-Радовић, Дана; Пергал, Марија; Несторов, Јелена; Aнтиц, Весна В.;
dc.citation.volume23
dc.citation.issue13
dc.citation.spage1629
dc.citation.epage1657
dc.citation.other23(13): 1629-1657
dc.citation.rankM22
dc.identifier.pmid21888759
dc.identifier.doi10.1163/092050611X589338
dc.identifier.rcubConv_2839
dc.identifier.scopus2-s2.0-84864626226
dc.identifier.wos000308105900001
dc.type.versionpublishedVersion


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