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Preparation of floating polymer-valsartan delivery systems using supercritical CO2
(Springer, 2021)
This study investigates pharmaceutical polymers (Soluplus®, HPMCAS, and Eudragit® E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa ...
Newly Synthesized Fluorinated Cinnamylpiperazines Possessing Low In Vitro MAO-B Binding
(MDPI, 2020)
Herein, we report on the synthesis and pharmacological evaluation of ten novel fluorinated cinnamylpiperazines as potential monoamine oxidase B (MAO-B) ligands. The designed derivatives consist of either cinnamyl or ...
In vitro and in vivo evaluation of fluorinated indanone derivatives as potential positron emission tomography agents for the imaging of monoamine oxidase B in the brain
(Elsevier, 2021)
Monoamine oxidases (MAOs) play a key role in the metabolism of major monoamine neurotransmitters. In particular, the upregulation of MAO-B in Parkinson's disease, Alzheimer's disease and cancer augmented the development ...
Investigation of lipophilicity and pharmacokinetic properties of 2-(methoxy) phenylpiperazine dopamine D2 ligands
(Elsevier, 2019)
Reversed-phase thin-layer chromatography and micellar thin-layer chromatography were used in order to investigate retention behaviour and to determine lipophilicity of series of 2(methoxy)phenylpiperazine dopamine D2 ligands ...
How aromatic system size affects the sensitivities of highly energetic molecules?
(Royal Society of Chemistry, 2021)
Positive values of electrostatic potentials above the central regions of the molecular surface are strongly related to the high sensitivities of highly energetic molecules. The influence of aromatic system size on the ...
Recombinant Bet v 1-BanLec chimera modulates functional characteristics of peritoneal murine macrophages by promoting IL-10 secretion
(Elsevier, 2021)
Allergen-specific immunotherapy (AIT) is a desensitizing treatment for allergic diseases that corrects the underlined pathological immune response to innocuous protein antigens, called allergens. Recombinant allergens ...
Influence of microstructure and roughness level on corrosion resistance of the austenitic stainless steel welded joint
(Wiley, 2021)
The influence of microstructure and surface roughness of the X5CrNi18-10 austenitic stainless steel-welded joint on resistance to uniform, pitting, and intergranular corrosion, as well as on the stability of the passive ...
Novel derivatives of aroylacrylic acid phenylamides as inducers of apoptosis through the ROS-mediated pathway in several cancer cell lines
(Elsevier, 2022)
In the present work, the α, β-double bond of the aroylacrylic acid phenylamides was suitably modified to optimize the toxicity–antiproliferative activity ratio of the resulting compounds 1 –5 . The phenylamides were modified ...
Effectiveness of Nature-Based Solutions in Mitigating Flood Hazard in a Mediterranean Peri-Urban Catchment
(MDPI, 2020)
Urbanization alters natural hydrological processes and enhances runoff, which affects flood hazard. Interest in nature-based solutions (NBS) for sustainable mitigation and adaptation to urban floods is growing, but the ...
A new species of Leonhardia Reitter, 1901 (Coleoptera, Leiodidae, Leptodirini) from Bosnia and Herzegovina, with a key to species of the genus
(Pensoft Publishers, 2021)
A new leptodirine leiodid beetle species belonging to the genus Leonhardia Reitter, 1901, L. solaki sp. nov., from a pit in Bosnia and Herzegovina (western Balkan Peninsula) is described and diagnosed. Important morphological ...