TY  - JOUR
AU  - Opsenica, Dejan
AU  - Terzić-Jovanović, Nataša
AU  - Smith, P.L.
AU  - Yang, Y.
AU  - Anova, L.
AU  - Smith, K. S.
AU  - Šolaja, Bogdan
PY  - 2008
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/444
AB  - Eleven new tetraoxanes possessing cholic acid-derived carrier and isopropylidene moiety were synthesized and were tested in vitro and in vivo. In vitro screening revealed that nine of them were more potent against CQ-resistant W2 than CQ-susceptible D6 strain and that two of them were equally or more potent than artemisinin and mefloquine against multi-drug resistant TM91C235 strain. Amine 8 cured all mice at the dose of 160 mg/kg/day, while the anilide 9 exhibited MCD ≤ 20 mg/kg/day. The diol 13 was most potent antiproliferative with GI50, TGI, LC50 MG_MID 0.98 μM, 3.80 μM, 11.22 μM, respectively. All tested compounds showed no toxic effects.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Bioorganic and Medicinal Chemistry
T1  - Mixed tetraoxanes containing the acetone subunit as antimalarials
VL  - 16
IS  - 14
SP  - 7039
EP  - 7045
DO  - 10.1016/j.bmc.2008.05.017
ER  - 

@article{
author = "Opsenica, Dejan and Terzić-Jovanović, Nataša and Smith, P.L. and Yang, Y. and Anova, L. and Smith, K. S. and Šolaja, Bogdan",
year = "2008",
abstract = "Eleven new tetraoxanes possessing cholic acid-derived carrier and isopropylidene moiety were synthesized and were tested in vitro and in vivo. In vitro screening revealed that nine of them were more potent against CQ-resistant W2 than CQ-susceptible D6 strain and that two of them were equally or more potent than artemisinin and mefloquine against multi-drug resistant TM91C235 strain. Amine 8 cured all mice at the dose of 160 mg/kg/day, while the anilide 9 exhibited MCD ≤ 20 mg/kg/day. The diol 13 was most potent antiproliferative with GI50, TGI, LC50 MG_MID 0.98 μM, 3.80 μM, 11.22 μM, respectively. All tested compounds showed no toxic effects.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Bioorganic and Medicinal Chemistry",
title = "Mixed tetraoxanes containing the acetone subunit as antimalarials",
volume = "16",
number = "14",
pages = "7039-7045",
doi = "10.1016/j.bmc.2008.05.017"
}

Opsenica, D., Terzić-Jovanović, N., Smith, P.L., Yang, Y., Anova, L., Smith, K. S.,& Šolaja, B.. (2008). Mixed tetraoxanes containing the acetone subunit as antimalarials. in Bioorganic and Medicinal Chemistry
Oxford : Pergamon-Elsevier Science Ltd., 16(14), 7039-7045.
https://doi.org/10.1016/j.bmc.2008.05.017

Opsenica D, Terzić-Jovanović N, Smith P, Yang Y, Anova L, Smith KS, Šolaja B. Mixed tetraoxanes containing the acetone subunit as antimalarials. in Bioorganic and Medicinal Chemistry. 2008;16(14):7039-7045.
doi:10.1016/j.bmc.2008.05.017 .

Opsenica, Dejan, Terzić-Jovanović, Nataša, Smith, P.L., Yang, Y., Anova, L., Smith, K. S., Šolaja, Bogdan, "Mixed tetraoxanes containing the acetone subunit as antimalarials" in Bioorganic and Medicinal Chemistry, 16, no. 14 (2008):7039-7045,
https://doi.org/10.1016/j.bmc.2008.05.017 . .

TY  - CONF
AU  - Šolaja, Bogdan
AU  - Terzić, Nataša
AU  - Smith, K. S.
AU  - Opsenica, Dejan
AU  - Smith, PL
AU  - Milhous, Wilbur K.
PY  - 2005
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2836
PB  - American Chemical Society (ACS)
C3  - Abstracts of papers of the American Chemical Society
T1  - Reductive cleavage of 1,2,4,5-tetraoxane antimalarials
VL  - 230
UR  - https://hdl.handle.net/21.15107/rcub_cherry_774
ER  - 

@conference{
author = "Šolaja, Bogdan and Terzić, Nataša and Smith, K. S. and Opsenica, Dejan and Smith, PL and Milhous, Wilbur K.",
year = "2005",
publisher = "American Chemical Society (ACS)",
journal = "Abstracts of papers of the American Chemical Society",
title = "Reductive cleavage of 1,2,4,5-tetraoxane antimalarials",
volume = "230",
url = "https://hdl.handle.net/21.15107/rcub_cherry_774"
}

Šolaja, B., Terzić, N., Smith, K. S., Opsenica, D., Smith, P.,& Milhous, W. K.. (2005). Reductive cleavage of 1,2,4,5-tetraoxane antimalarials. in Abstracts of papers of the American Chemical Society
American Chemical Society (ACS)., 230.
https://hdl.handle.net/21.15107/rcub_cherry_774

Šolaja B, Terzić N, Smith KS, Opsenica D, Smith P, Milhous WK. Reductive cleavage of 1,2,4,5-tetraoxane antimalarials. in Abstracts of papers of the American Chemical Society. 2005;230.
https://hdl.handle.net/21.15107/rcub_cherry_774 .

Šolaja, Bogdan, Terzić, Nataša, Smith, K. S., Opsenica, Dejan, Smith, PL, Milhous, Wilbur K., "Reductive cleavage of 1,2,4,5-tetraoxane antimalarials" in Abstracts of papers of the American Chemical Society, 230 (2005),
https://hdl.handle.net/21.15107/rcub_cherry_774 .